Vicodin and Nplate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vicodin (acetaminophen; hydrocodone bitartrate) and Nplate (romiplostim). Common drug interactions include platelet count decreased among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Vicodin and Nplate. It is created by eHealthMe based on reports of 94 people who take the same drugs from the FDA, and is updated regularly.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

What is Nplate?

Nplate has active ingredients of romiplostim. It is often used in idiopathic thrombocytopenic purpura (itp). eHealthMe is studying from 17,850 Nplate users. Check the latest studies of Nplate.

On Aug, 03, 2026

94 people who take Vicodin and Nplate together, and have interactions are studied.

What are the common drug interactions of Vicodin and Nplate, by gender? *:

female:

Platelet count decreased
Contusion (a type of hematoma of tissue in which capillaries)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Arthralgia (joint pain)
Petechiae (a small red or purple spot caused by bleeding into the skin)
Asthenia (weakness)
Oedema peripheral (superficial swelling)
Pulmonary embolism (blockage of the main artery of the lung)
Fatigue (feeling of tiredness)
Myalgia (muscle pain)

male:

Asthenia (weakness)
Petechiae (a small red or purple spot caused by bleeding into the skin)
Bone marrow failure
Enterocolitis infectious
Hypokalaemia (low potassium)
Influenza like illness
Pseudohyperkalaemia (marked increase of in vitro serum potassium levels)
Purpura (purplish discoloration of the skin)
Septic shock (shock due to blood infection)
Urinary hesitation (difficulty in beginning the flow of urine)

What are the common drug interactions of Vicodin and Nplate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Platelet count decreased
Abortion spontaneous (naturally occurring miscarriage)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Embolism venous (embolus may pass into the arterial system)
Infertility female
Scleroderma (hard skin)
Therapeutic response decreased (less preventive response)
Vaginal haemorrhage (vaginal bleeding)
Viith nerve paralysis

30-39:

Metastases to lung (cancer spreads to lung)
Pulmonary embolism (blockage of the main artery of the lung)

40-49:

Contusion (a type of hematoma of tissue in which capillaries)
Petechiae (a small red or purple spot caused by bleeding into the skin)
Abdominal pain
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Neuropathy peripheral (surface nerve damage)
Oedema peripheral (superficial swelling)
Pain in extremity
Pruritus (severe itching of the skin)
Therapeutic response decreased (less preventive response)
Therapeutic response unexpected

50-59:

Anaemia (lack of blood)
Anti-hbc igg antibody positive
Arthralgia (joint pain)
Asthenia (weakness)
Bone marrow reticulin fibrosis (thickening and scarring of bone marrow reticulin)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chronic lymphocytic leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell))
Coagulopathy (blood's ability to clot is impaired)
Confusional state
Depressed mood

60+:

Thrombocytopenia (decrease of platelets in blood)
Therapeutic response decreased (less preventive response)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Anaemia (lack of blood)
Pleural effusion (water on the lungs)
Pneumonia
Arthralgia (joint pain)
Benign prostatic hyperplasia (benign enlargement of the prostate)
Bone marrow failure
Enterocolitis infectious

What are the existing conditions these people have? *

Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 89 people, 94.68%
Anaemia (lack of blood): 8 people, 8.51%
Nausea (feeling of having an urge to vomit): 5 people, 5.32%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 5 people, 5.32%

* Approximation only. Some reports may have incomplete information.

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