Vicodin and Nuplazid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vicodin (acetaminophen; hydrocodone bitartrate) and Nuplazid (pimavanserin tartrate). Common drug interactions include hallucination among females and hallucination among males.

The phase IV clinical study analyzes what interactions people have when they take Vicodin and Nuplazid. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

What is Nuplazid?

Nuplazid has active ingredients of pimavanserin tartrate. eHealthMe is studying from 47,103 Nuplazid users. Check the latest studies of Nuplazid.

On Jul, 14, 2026

25 people who take Vicodin and Nuplazid together, and have interactions are studied.

What are the common drug interactions of Vicodin and Nuplazid, by gender? *:

female:

Hallucination (an experience involving the perception of something not present)
Syncope (loss of consciousness with an inability to maintain postural tone)
Confusional state
Drug effect decreased
Hypoacusis (loss of hearing)
Throat irritation
Delusion (a false belief or opinion)
Death
Dizziness
Malaise (a feeling of general discomfort or uneasiness)

male:

Hallucination (an experience involving the perception of something not present)
Cough
Unresponsive to stimuli
Urinary tract infection
Asthenia (weakness)
Decreased appetite
General physical health deterioration (weak health status)
Infection
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the common drug interactions of Vicodin and Nuplazid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Adverse drug reaction
Asthenia (weakness)
Balance disorder
Gait disturbance
Head discomfort
Lethargy (tiredness)

60+:

Hallucination (an experience involving the perception of something not present)
Drug ineffective
Unresponsive to stimuli
Syncope (loss of consciousness with an inability to maintain postural tone)
Asthenia (weakness)
Decreased appetite
Drug effect decreased
General physical health deterioration (weak health status)
Hypoacusis (loss of hearing)
Infection

What are the existing conditions these people have? *

Hallucinations (sensations that appear real but are created by your mind): 17 people, 68.00%
Delusion (a false belief or opinion): 17 people, 68.00%
Parkinson's Disease: 11 people, 44.00%
Psychotic Disorder Due To A General Medical Condition: 6 people, 24.00%
Infection: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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