Vicodin and Vimovo drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vicodin (acetaminophen; hydrocodone bitartrate) and Vimovo (esomeprazole magnesium; naproxen). Common drug interactions include chronic kidney disease among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Vicodin and Vimovo. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

What is Vimovo?

Vimovo has active ingredients of esomeprazole magnesium; naproxen. It is often used in osteoarthritis. eHealthMe is studying from 9,608 Vimovo users. Check the latest studies of Vimovo.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

29 people who take Vicodin and Vimovo together, and have interactions are studied.

What are the common drug interactions of Vicodin and Vimovo, by gender? *:

female:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Death
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Renal failure (kidney dysfunction)
Gastritis (inflammation of stomach)
Compression fracture (fracture due to pressure caused by injury)
Constipation
Fall
Fatigue (feeling of tiredness)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Haematochezia (passage of stools containing blood)
Renal injury (kidney injury)
Cardiac failure congestive
Death
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nephropathy (damage to or disease of a kidney)

What are the common drug interactions of Vicodin and Vimovo, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

40-49:

Abdominal discomfort
Diarrhoea

50-59:

Cardiac failure congestive
Headache (pain in head)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Anxiety
Depression
Dizziness
Dyspepsia (indigestion)
Emotional disorder
Gastritis (inflammation of stomach)
Gastrointestinal inflammation (inflammation of stomach and intestine)

60+:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Chest discomfort
Dyspnoea (difficult or laboured respiration)
Haematochezia (passage of stools containing blood)
Death
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 34.48%
Hypersensitivity: 4 people, 13.79%
High Blood Pressure: 3 people, 10.34%
Blood Disorder: 3 people, 10.34%
Gastric Disorder (disease of stomach): 3 people, 10.34%
Gastric Ulcer (stomach ulcer): 3 people, 10.34%
Renal Disorder (kidney disease): 3 people, 10.34%
Asthma: 3 people, 10.34%
Joint Pain: 3 people, 10.34%
Neuralgia (pain in one or more nerves): 3 people, 10.34%

* Approximation only. Some reports may have incomplete information.

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