Vimpat and Dantrium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vimpat (lacosamide) and Dantrium (dantrolene sodium). Common drug interactions include fatigue among females and angioedema among males.

The phase IV clinical study analyzes what interactions people have when they take Vimpat and Dantrium. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Vimpat?

Vimpat has active ingredients of lacosamide. It is often used in epilepsy. eHealthMe is studying from 20,832 Vimpat users. Check the latest studies of Vimpat.

What is Dantrium?

Dantrium has active ingredients of dantrolene sodium. eHealthMe is studying from 1,408 Dantrium users. Check the latest studies of Dantrium.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

12 people who take Vimpat and Dantrium together, and have interactions are studied.

What are the common drug interactions of Vimpat and Dantrium, by gender? *:

female:

Fatigue (feeling of tiredness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Hypersomnia (excessive daytime sleepiness (eds))
Bladder disorder
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Salivary hypersecretion (excess saliva secretion)
Vomiting
Abdominal discomfort

male:

Angioedema (rapid swelling of the dermis)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Balance disorder
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Drug eruption (adverse drug reaction of the skin)

What are the common drug interactions of Vimpat and Dantrium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Drug eruption (adverse drug reaction of the skin)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

10-19:

n/a

20-29:

Somnolence (a state of near-sleep, a strong desire for sleep)
Fatigue (feeling of tiredness)
Hypersomnia (excessive daytime sleepiness (eds))
Angioedema (rapid swelling of the dermis)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Salivary hypersecretion (excess saliva secretion)

30-39:

Abdominal pain
Bladder disorder
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Fatigue (feeling of tiredness)
Headache (pain in head)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

40-49:

n/a

50-59:

Fatigue (feeling of tiredness)
Functional gastrointestinal disorder (functional problem in separate organs of gastrointestinal system)
Hand fracture
Hypotension (abnormally low blood pressure)
Limb injury
Migraine (headache)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscle spasms (muscle contraction)
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

60+:

Fall
Partial seizures (seizures which affect only a part of the brain at onset)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 25.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 16.67%
Staphylococcal Infection (an infection with staphylococcus bacteria): 1 person, 8.33%
Seizure Cluster (small group of seizure): 1 person, 8.33%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 1 person, 8.33%
Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 1 person, 8.33%
Gait Disturbance: 1 person, 8.33%
Fatigue (feeling of tiredness): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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