Vistaril and Clozapine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vistaril (hydroxyzine hydrochloride) and Clozapine (clozapine). Common drug interactions include hepatomegaly among females and vomiting among males.

The phase IV clinical study analyzes what interactions people have when they take Vistaril and Clozapine. It is created by eHealthMe based on reports of 76 people who take the same drugs from the FDA, and is updated regularly.

What is Vistaril?

Vistaril has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 9,565 Vistaril users. Check the latest studies of Vistaril.

What is Clozapine?

Clozapine has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 83,728 Clozapine users. Check the latest studies of Clozapine.

On Jul, 15, 2026

76 people who take Vistaril and Clozapine together, and have interactions are studied.

Vistaril and Clozapine drug interactions.

What are the common drug interactions of Vistaril and Clozapine, by gender? *:

female:

Hepatomegaly (abnormal enlargement of the liver)
Hyperhidrosis (abnormally increased sweating)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Leukocytosis (increased white blood cells)
Local swelling (swelling at the site of some application of substance or injury)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Pyrexia (fever)

male:

Vomiting
Granulocytopenia (lack of granulocyte)
Leukopenia (less number of white blood cells in blood)
Asthenia (weakness)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Constipation
Drug level increased
Hypotension (abnormally low blood pressure)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pyrexia (fever)

What are the common drug interactions of Vistaril and Clozapine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Suicide attempt

20-29:

Neutropenia (an abnormally low number of neutrophils)

30-39:

Granulocytopenia (lack of granulocyte)
Antipsychotic drug level increased
Diarrhoea
Gastroenteritis (inflammation of stomach and intestine)
Ileus paralytic (obstruction of the intestine due to paralysis of the intestinal muscles)
Pneumonia
Vomiting
Hypotension (abnormally low blood pressure)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Neutropenia (an abnormally low number of neutrophils)

40-49:

Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Pain in extremity
Palmar erythema (reddening of the palms at the thenar and hypothenar eminences)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Polycythaemia (proportion of blood volume that is occupied by red blood cells increases)
Polycythaemia vera (blood disorder in which the bone marrow makes too many red blood cells)
Pruritus (severe itching of the skin)
Rash
Somnolence (a state of near-sleep, a strong desire for sleep)

50-59:

Neutropenia (an abnormally low number of neutrophils)
Leukopenia (less number of white blood cells in blood)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Granulocytopenia (lack of granulocyte)
Constipation
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Sedation
Thrombocytopenia (decrease of platelets in blood)
White blood cell count increased
Agitation (state of anxiety or nervous excitement)

60+:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Neutropenia (an abnormally low number of neutrophils)
Pneumonia
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sepsis (a severe blood infection that can lead to organ failure and death)
Apnoea (suspension of external breathing)
Coma (state of unconsciousness lasting more than six hours)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Schizoaffective Disorder (a mental disorder characterized by disordered thought): 12 people, 15.79%
Psychotic Disorder: 4 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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