Vistaril and Pamelor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vistaril (hydroxyzine hydrochloride) and Pamelor (nortriptyline hydrochloride). Common drug interactions include nausea among females and arrhythmia among males.

The phase IV clinical study analyzes what interactions people have when they take Vistaril and Pamelor. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Vistaril?

Vistaril has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 9,565 Vistaril users. Check the latest studies of Vistaril.

What is Pamelor?

Pamelor has active ingredients of nortriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 4,069 Pamelor users. Check the latest studies of Pamelor.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

35 people who take Vistaril and Pamelor together, and have interactions are studied.

What are the common drug interactions of Vistaril and Pamelor, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Pain
Weight decreased
Blood cholesterol increased
Blood triglycerides increased
Abdominal pain upper
Alopecia (absence of hair from areas of the body)
Application site rash
Arteriosclerosis (thickening and hardening of arteries)
Arthralgia (joint pain)

male:

Arrhythmia (irregular heartbeat)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dyspnoea (difficult or laboured respiration)
Echocardiogram abnormal
Electrocardiogram abnormal
Electrocardiogram qt prolonged
Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Mitral valve incompetence (inefficient heart valve)

What are the common drug interactions of Vistaril and Pamelor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain upper
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Eye injury
Fatigue (feeling of tiredness)
Hepatic enzyme increased
Hypoaesthesia (reduced sense of touch or sensation)
Irritability
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Neuropathy peripheral (surface nerve damage)

30-39:

Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Arrhythmia (irregular heartbeat)
Cardiomyopathy (weakening of the heart muscle)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Osteomyelitis (infection of bone)
Palpitations (feelings or sensations that your heart is pounding or racing)
Weight increased
Echocardiogram abnormal
Electrocardiogram abnormal

40-49:

Rash erythematous (redness of the skin)
Rectal bleeding (bleeding from rectum)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Sore throat (pain or irritation of the throat)
Spondylosis (a defect of a vertebra)
Urinary retention (the inability to completely or partially empty the bladder)
Ventricular extrasystoles (premature cardiac contraction)
Vision blurred
Weakness
Abnormal behaviour

50-59:

Abdominal pain upper
Abdominal tenderness
Bile duct stone
Blood bilirubin increased
Blood cholesterol increased
Blood immunoglobulin g increased
Blood triglycerides increased
Cholangitis (infection of the bile duct)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic kidney disease

60+:

Acute respiratory failure
Cardiogenic shock (inadequate circulation of blood)
Overdose
Red blood cell count increased
Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Pulmonary embolism (blockage of the main artery of the lung)
Renal failure (kidney dysfunction)
Application site rash
Renal tubular necrosis (death of kidney tubules)

What are the existing conditions these people have? *

Pain: 9 people, 25.71%
Bipolar Disorder (mood disorder): 4 people, 11.43%
Wheezing (a high-pitched whistling sound made while you breath): 3 people, 8.57%
Headache (pain in head): 3 people, 8.57%
Sleep Disorder: 3 people, 8.57%
Muscle Spasms (muscle contraction): 3 people, 8.57%
Dyspnea (difficult or laboured breathing): 3 people, 8.57%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 8.57%
Asthma: 2 people, 5.71%
Depression: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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