Vistaril and Plaquenil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vistaril (hydroxyzine hydrochloride) and Plaquenil (hydroxychloroquine sulfate). Common drug interactions include blood parathyroid hormone increased among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Vistaril and Plaquenil. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Vistaril?

Vistaril has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 9,565 Vistaril users. Check the latest studies of Vistaril.

What is Plaquenil?

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. eHealthMe is studying from 91,018 Plaquenil users. Check the latest studies of Plaquenil.

On Jul, 07, 2026

75 people who take Vistaril and Plaquenil together, and have interactions are studied.

Vistaril and Plaquenil drug interactions.

What are the common drug interactions of Vistaril and Plaquenil, by gender? *:

female:

Blood parathyroid hormone increased
Cardiomegaly (increased size of heart than normal)
Cough
Cutaneous lupus erythematosus (own immune system attacks various cells causing a wide variety of signs and symptoms)
Depression
Dyskinesia (abnormality or impairment of voluntary movement)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Homicidal ideation (thoughts about human killing another human)

male:

Depression
Drug abuser
Pyrexia (fever)
Rash
Abdominal pain
Chest pain
Diarrhoea
Drug addiction
Dyspnoea (difficult or laboured respiration)
Laceration (tearing of soft body tissue)

What are the common drug interactions of Vistaril and Plaquenil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Myalgia (muscle pain)
Upper respiratory tract infection
Activities of daily living impaired
Arthralgia (joint pain)
Back pain
Bedridden
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cholecystitis chronic (long lasting infection of gallbladder)
Decreased interest
Depression

30-39:

Ankylosing spondylitis (type of arthritis affecting the spine)
Drug ineffective
Headache (pain in head)
Immune system disorder
Oropharyngeal pain
Pain
Rash
Respiratory tract infection
Restlessness (not able to rest)
Sinus disorder (disease of sinus)

40-49:

Drug ineffective
Pain
Depression
Drug abuser
Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Synovitis (inflammation of the synovial membrane)
Back injury
Chest pain
Dehydration (dryness resulting from the removal of water)

50-59:

Nausea (feeling of having an urge to vomit)
Neurosarcoidosis (a condition of unknown cause featuring a collection of immune cells in various tissues, involving the central nervous system (brain and spinal cord))
Oral disorder (mouth disease)
Oral mucosal blistering (mouth ulcer)
Oral pain
Oral surgery
Osteonecrosis (death of bone)
Oxygen saturation decreased
Pancreatitis (inflammation of pancreas)
Postoperative wound infection

60+:

Anaemia (lack of blood)
Cardiac arrest
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Sepsis (a severe blood infection that can lead to organ failure and death)
Headache (pain in head)
Acute respiratory distress syndrome
Asthenia (weakness)
Bedridden
Bone cyst
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 27 people, 36.00%
Pain: 13 people, 17.33%
Fibromyalgia (a long-term condition which causes pain all over the body): 13 people, 17.33%
Respiratory Disorder (respiratory disease): 8 people, 10.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 9.33%
Ankylosing Spondylitis (type of arthritis affecting the spine): 6 people, 8.00%
Depression: 6 people, 8.00%
Itching: 6 people, 8.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 6.67%
Thyroid Diseases: 5 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Vistaril and Plaquenil?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously