Vistaril and Savella drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vistaril (hydroxyzine hydrochloride) and Savella (milnacipran hydrochloride). Common drug interactions include renal failure among females and joint effusion among males.

The phase IV clinical study analyzes what interactions people have when they take Vistaril and Savella. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Vistaril?

Vistaril has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 9,565 Vistaril users. Check the latest studies of Vistaril.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 16, 2026

32 people who take Vistaril and Savella together, and have interactions are studied.

What are the common drug interactions of Vistaril and Savella, by gender? *:

female:

Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Nausea (feeling of having an urge to vomit)
Vomiting
Dizziness
Fall
Asthenia (weakness)
Circulatory collapse
Constipation
Drug ineffective

male:

Joint effusion (presence of extra fluid in joint covering)
Muscle rupture (tear in muscle)
Incision site haemorrhage (bleeding from incision site)
Skin burning sensation
Skin tightness
Somnolence (a state of near-sleep, a strong desire for sleep)
Vertigo
Pain in extremity
Peripheral swelling
Skin discolouration (change of skin colour)

What are the common drug interactions of Vistaril and Savella, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Joint effusion (presence of extra fluid in joint covering)
Muscle rupture (tear in muscle)
Pain in extremity
Peripheral swelling
Skin discolouration (change of skin colour)
Thrombosis (formation of a blood clot inside a blood vessel)
Alopecia (absence of hair from areas of the body)
Fatigue (feeling of tiredness)
Incision site haemorrhage (bleeding from incision site)

40-49:

Dry eye (lack of adequate tears)
Age-related macular degeneration
Therapeutic response decreased (less preventive response)
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Abdominal pain
Chronic kidney disease
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Dehydration (dryness resulting from the removal of water)
Dizziness

50-59:

Dizziness
Faecaloma (hard mass of fecal matter)
Fall
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Nausea (feeling of having an urge to vomit)
Partial seizures (seizures which affect only a part of the brain at onset)
Tremor (trembling or shaking movements in one or more parts of your body)
Unresponsive to stimuli
Visual impairment
Activities of daily living impaired

60+:

Nausea (feeling of having an urge to vomit)
Vomiting
Arthralgia (joint pain)
Diarrhoea
Drug ineffective
Eructation (release of gas from the digestive tract)
Headache (pain in head)

What are the existing conditions these people have? *

Migraine (headache): 6 people, 18.75%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 18.75%
Pain: 5 people, 15.62%
Insomnia (sleeplessness): 5 people, 15.62%
Muscle Spasms (muscle contraction): 5 people, 15.62%
Nausea (feeling of having an urge to vomit): 5 people, 15.62%
Sleep Disorder: 5 people, 15.62%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 15.62%
Depression: 4 people, 12.50%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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