Vistaril and Stelazine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vistaril (hydroxyzine hydrochloride) and Stelazine (trifluoperazine hydrochloride). Common drug interactions include diabetic ketoacidosis among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Vistaril and Stelazine. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Vistaril?

Vistaril has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 9,565 Vistaril users. Check the latest studies of Vistaril.

What is Stelazine?

Stelazine has active ingredients of trifluoperazine hydrochloride. It is often used in schizophrenia. eHealthMe is studying from 1,311 Stelazine users. Check the latest studies of Stelazine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

18 people who take Vistaril and Stelazine together, and have interactions are studied.

Vistaril and Stelazine drug interactions.

What are the common drug interactions of Vistaril and Stelazine, by gender? *:

female:

Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Drug addiction
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Gallbladder disorder
Gastrointestinal mucosal disorder (disorder of gastrointestinal lining mucous membranes)
Generalised oedema (swelling all over the body)
Hypersensitivity
Hypertension (high blood pressure)
Insulin resistance

male:

Abdominal pain
Chest discomfort
Periumbilical abscess (abscess around the umbilicus)
Polysubstance dependence
Psychotic disorder
Schizoaffective disorder (a mental disorder characterized by disordered thought)
Schizophrenia, paranoid type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect)
Sinusitis (inflammation of sinus)
Type 2 diabetes mellitus
Blood glucose increased

What are the common drug interactions of Vistaril and Stelazine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chest discomfort
Chest pain
Diabetic coma
Facial palsy (paralysis of face nerve)
Hypertension (high blood pressure)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Infection
Peptic ulcer
Periumbilical abscess (abscess around the umbilicus)
Polysubstance dependence

40-49:

Blood cholesterol increased
Obesity (having too much body fat)
Type 2 diabetes mellitus
Pancreatitis (inflammation of pancreas)
Abdominal pain
Abdominal pain upper
Arrhythmia (irregular heartbeat)
Arthralgia (joint pain)
Asthenia (weakness)
Back pain

50-59:

Gallbladder disorder
Hyperglycaemia (high blood sugar)
Hypertension (high blood pressure)
Intervertebral disc disorder (spinal disc disorder)
Irritable bowel syndrome
Lymphadenopathy (disease or enlargement of lymph nodes)
Mania (a state of abnormally elevated or irritable mood)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Suicidal behaviour

60+:

Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Gait disturbance
Hyperglycaemia (high blood sugar)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Type 2 diabetes mellitus

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 7 people, 38.89%
Sleep Disorder: 5 people, 27.78%
Depression: 5 people, 27.78%
Nausea (feeling of having an urge to vomit): 4 people, 22.22%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 4 people, 22.22%
Pain: 4 people, 22.22%
Nausea And Vomiting: 4 people, 22.22%
Insomnia (sleeplessness): 4 people, 22.22%
Psychotic Disorder: 2 people, 11.11%
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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