Vistaril and Sudafed drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vistaril (hydroxyzine hydrochloride) and Sudafed (pseudoephedrine hydrochloride). Common drug interactions include depression among females and tremor among males.

The phase IV clinical study analyzes what interactions people have when they take Vistaril and Sudafed. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Vistaril?

Vistaril has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 9,565 Vistaril users. Check the latest studies of Vistaril.

What is Sudafed?

Sudafed has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 12,944 Sudafed users. Check the latest studies of Sudafed.

On Jul, 08, 2026

24 people who take Vistaril and Sudafed together, and have interactions are studied.

What are the common drug interactions of Vistaril and Sudafed, by gender? *:

female:

Depression
Dehydration (dryness resulting from the removal of water)
Nausea (feeling of having an urge to vomit)
Abdominal pain lower
Alopecia (absence of hair from areas of the body)
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Anal atresia (anus is either not present or it is in the wrong place)
Anal fistula
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Drug ineffective

male:

Tremor (trembling or shaking movements in one or more parts of your body)
Weight decreased
Emotional distress
Facial palsy (paralysis of face nerve)
Feeling jittery
Gastrointestinal motility disorder (abnormal intestinal contractions)
Gastrointestinal pain
Haematochezia (passage of stools containing blood)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Migraine (headache)

What are the common drug interactions of Vistaril and Sudafed, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Infusion site erythema (reddening of the skin at infusion site)
Infusion site pain
Infusion site swelling
Infusion site warmth

20-29:

Depression
Abdominal pain lower
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Dysmenorrhoea (painful menstruation)
Ectopic pregnancy (a pregnancy in which the foetus develops outside the uterus, typically in a fallopian tube)
Haemoperitoneum (presence of blood in the peritoneal cavity)
Impaired healing
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Menstruation irregular
Migraine (headache)

30-39:

Drug dependence
Feeling jittery
Mood swings (an extreme or rapid change in mood)
Palpitations (feelings or sensations that your heart is pounding or racing)
Self-injurious ideation
Tremor (trembling or shaking movements in one or more parts of your body)
Viral infection
Weight decreased

40-49:

Drug ineffective
Alopecia (absence of hair from areas of the body)
Chronic kidney disease
Creatine urine decreased
Creatinine renal clearance decreased
Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)
Hair colour changes
Hair disorder
Laboratory test abnormal

50-59:

Abdominal pain upper
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Depression
Diarrhoea
Fatigue (feeling of tiredness)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Nervousness
Varicose vein (veins that have become enlarged and tortuous)

60+:

Contusion (a type of hematoma of tissue in which capillaries)
Drug hypersensitivity
Emergency care
Fall
Headache (pain in head)
Hip fracture
Lower limb fracture
Micturition urgency (urgency to pass the urine)

What are the existing conditions these people have? *

Sleep Disorder: 3 people, 12.50%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 12.50%
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 3 people, 12.50%
Rashes (redness): 2 people, 8.33%
Pain: 2 people, 8.33%
Neuropathy Peripheral (surface nerve damage): 2 people, 8.33%
Muscle Spasms (muscle contraction): 2 people, 8.33%
Migraine (headache): 2 people, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.33%
Drowsiness: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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