Vistaril and Zometa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vistaril (hydroxyzine hydrochloride) and Zometa (zoledronic acid). Common drug interactions include impaired healing among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Vistaril and Zometa. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Vistaril?

Vistaril has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 9,565 Vistaril users. Check the latest studies of Vistaril.

What is Zometa?

Zometa has active ingredients of zoledronic acid. It is often used in multiple myeloma. eHealthMe is studying from 71,434 Zometa users. Check the latest studies of Zometa.



On Jul, 16, 2026

75 people who take Vistaril and Zometa together, and have interactions are studied.

Vistaril and Zometa drug interactions.

What are the common drug interactions of Vistaril and Zometa, by gender? *:

female:

  1. Impaired healing
  2. Pleural effusion (water on the lungs)
  3. Dehydration (dryness resulting from the removal of water)
  4. Erythema (redness of the skin)
  5. Gingival swelling (gums swelling)
  6. Deformity (disfigurement)
  7. Metastases to liver (cancer spreads to liver)
  8. Lymphadenopathy (disease or enlargement of lymph nodes)
  9. Osteomyelitis (infection of bone)
  10. Vomiting

male:

  1. Pain
  2. Diarrhoea
  3. Dysphagia (a condition in which swallowing is difficult or painful)
  4. Osteomyelitis (infection of bone)
  5. Pleural effusion (water on the lungs)
  6. Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
  7. Dental caries
  8. Injury
  9. Fall
  10. Pain in jaw

What are the common drug interactions of Vistaril and Zometa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Headache (pain in head)
  2. Abdominal pain
  3. Abdominal pain upper
  4. Alveolar osteitis (complication of wound healing following extraction of a tooth)
  5. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  6. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  7. Arthralgia (joint pain)
  8. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  9. Asthenia (weakness)
  10. Atelectasis (partial or complete collapse of the lung)

20-29:

n/a

30-39:

n/a

40-49:

  1. Arthralgia (joint pain)
  2. Blood calcium increased
  3. Blood potassium decreased
  4. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  5. Energy increased
  6. Fatigue (feeling of tiredness)
  7. Haematocrit decreased
  8. Haemoglobin decreased
  9. Lymphocyte count decreased
  10. Mean cell volume decreased (less of the average red blood cell volume)

50-59:

  1. Erythema (redness of the skin)
  2. Gingival swelling (gums swelling)
  3. Pain in jaw
  4. Pleural effusion (water on the lungs)
  5. Lymphadenopathy (disease or enlargement of lymph nodes)
  6. Osteomyelitis (infection of bone)
  7. General physical health deterioration (weak health status)
  8. Metastases to spine (cancer spreads to spine)
  9. Abasia (inability to walk)
  10. Ascites (accumulation of fluid in the abdominal cavity)

60+:

  1. Pain
  2. Vomiting
  3. Headache (pain in head)
  4. Pleural effusion (water on the lungs)
  5. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  6. Dysgeusia (disorder of the sense of taste)
  7. Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
  8. Depression
  9. Dysphagia (a condition in which swallowing is difficult or painful)
  10. Arthralgia (joint pain)

What are the existing conditions these people have? *

  1. Breast Cancer: 16 people, 21.33%
  2. Breast Cancer Metastatic: 13 people, 17.33%
  3. Neoplasm Malignant (cancer tumour): 12 people, 16.00%
  4. Constipation: 11 people, 14.67%
  5. High Blood Cholesterol: 9 people, 12.00%
  6. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 8 people, 10.67%
  7. High Blood Pressure: 8 people, 10.67%
  8. Metastases To Bone (cancer spreads to bone): 6 people, 8.00%
  9. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 6.67%
  10. Depression: 5 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Vistaril and Zometa?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Vistaril and Zometa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vistaril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Zometa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Vistaril and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zometa and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on hydroxyzine hydrochloride and zoledronic acid (the active ingredients of Vistaril and Zometa, respectively), and Vistaril and Zometa (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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