Vistaril and Zonegran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vistaril (hydroxyzine hydrochloride) and Zonegran (zonisamide). Common drug interactions include dyspnoea among females and diabetes mellitus among males.

The phase IV clinical study analyzes what interactions people have when they take Vistaril and Zonegran. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Vistaril?

Vistaril has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 9,565 Vistaril users. Check the latest studies of Vistaril.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

On Jul, 16, 2026

25 people who take Vistaril and Zonegran together, and have interactions are studied.

Vistaril and Zonegran drug interactions.

What are the common drug interactions of Vistaril and Zonegran, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Axillary mass
Axillary pain
Oropharyngeal discomfort (pain or irritation of oropharynx)
Peripheral swelling
Chronic kidney disease
Fluid retention (an abnormal accumulation of fluid in the blood)
Memory impairment
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)

male:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Suicidal ideation
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Neuropathy peripheral (surface nerve damage)
Type 2 diabetes mellitus
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Hyperglycaemia (high blood sugar)
Constipation
Drug ineffective
Dry mouth

What are the common drug interactions of Vistaril and Zonegran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Tremor (trembling or shaking movements in one or more parts of your body)

30-39:

Fluid retention (an abnormal accumulation of fluid in the blood)
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
Road traffic accident
Vestibular disorder (disorders of the body's balance (vestibular) system in the inner ear)
Weight increased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Surgery

40-49:

Axillary mass
Axillary pain
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Oropharyngeal discomfort (pain or irritation of oropharynx)
Peripheral swelling
Chronic kidney disease
Renal failure (kidney dysfunction)
Asthma
Disability

50-59:

Type 2 diabetes mellitus
Constipation
Drug ineffective
Dry mouth
Dyspnoea (difficult or laboured respiration)
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Hyperglycaemia (high blood sugar)
Neuropathy peripheral (surface nerve damage)

60+:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Suicidal ideation
Drug hypersensitivity
Neuropathy peripheral (surface nerve damage)
Type 2 diabetes mellitus

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 52.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 36.00%
Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 4 people, 16.00%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 4 people, 16.00%
Drowsiness: 4 people, 16.00%
Bipolar Disorder (mood disorder): 4 people, 16.00%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 4 people, 16.00%
High Blood Cholesterol: 3 people, 12.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 12.00%
Pain: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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