Vitamin b2 and Zofran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vitamin b2 (riboflavin) and Zofran (ondansetron hydrochloride). Common drug interactions include fluid overload among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Vitamin b2 and Zofran. It is created by eHealthMe based on reports of 87 people who take the same drugs from the FDA, and is updated regularly.

What is Vitamin b2?

Vitamin b2 has active ingredients of riboflavin. It is often used in migraine. eHealthMe is studying from 1,740 Vitamin b2 users. Check the latest studies of Vitamin b2.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.



On Jul, 18, 2026

87 people who take Vitamin b2 and Zofran together, and have interactions are studied.

Vitamin b2 and Zofran drug interactions.

What are the common drug interactions of Vitamin B2 and Zofran, by gender? *:

female:

  1. Fluid overload (too much fluid in the blood)
  2. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  3. Grip strength decreased
  4. Haematemesis (vomiting of blood)
  5. Haematocrit decreased
  6. Haemoglobin decreased
  7. Hypophagia (reduced food intake)
  8. Hypovolaemia (a decreased volume of circulating blood in the body)
  9. Hypoxia (low oxygen in tissues)
  10. Headache (pain in head)

male:

  1. Pneumonia
  2. Abdominal discomfort
  3. Fatigue (feeling of tiredness)
  4. Gastric disorder (disease of stomach)
  5. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  6. Headache (pain in head)
  7. Malaise (a feeling of general discomfort or uneasiness)
  8. Oesophageal disorder (disease of oesophagus)
  9. Procedural complication
  10. Vision blurred

What are the common drug interactions of Vitamin B2 and Zofran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Device related infection
  2. Enuresis (repeated inability to control urination)
  3. Hospitalisation

20-29:

  1. Drug ineffective
  2. Liver injury
  3. Procedural pain
  4. Abdominal discomfort
  5. Adrenal adenoma (benign tumour of the glandular type (adenoma) in the adrenal gland)
  6. Adrenal mass
  7. Adverse drug reaction
  8. Anxiety
  9. Blood testosterone free increased
  10. Decreased appetite

30-39:

  1. Anxiety
  2. Cough
  3. Cystitis haemorrhagic (blood in the urine and painful voiding)
  4. Fracture
  5. Headache (pain in head)
  6. Hypertension (high blood pressure)
  7. Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
  8. Oropharyngeal pain
  9. Pain
  10. Pain in extremity

40-49:

  1. Headache (pain in head)
  2. Peripheral swelling
  3. Weight increased
  4. Blood cholesterol increased
  5. Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
  6. Neck pain
  7. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  8. Diarrhoea
  9. Dyspnoea exertional (breathlessness or shortness of breath)
  10. Pallor

50-59:

  1. Blood pressure increased
  2. Brain natriuretic peptide increased
  3. Chest discomfort
  4. Chest pain
  5. Constipation
  6. Cough
  7. Decreased appetite
  8. Device dislocation
  9. Disease progression
  10. Dysphagia (a condition in which swallowing is difficult or painful)

60+:

  1. Pallor
  2. Constipation
  3. Anxiety
  4. Malaise (a feeling of general discomfort or uneasiness)
  5. Weight decreased
  6. Eye pruritus (eye itching)
  7. Arthralgia (joint pain)
  8. Depression
  9. Diarrhoea
  10. Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 10 people, 11.49%
  2. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 10 people, 11.49%
  3. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 8 people, 9.20%
  4. Stress And Anxiety: 7 people, 8.05%
  5. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 8.05%
  6. Headache (pain in head): 7 people, 8.05%

* Approximation only. Some reports may have incomplete information.

Do you take Vitamin b2 and Zofran?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Vitamin b2 and Zofran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vitamin b2:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Zofran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Vitamin b2 and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zofran and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on riboflavin and ondansetron hydrochloride (the active ingredients of Vitamin b2 and Zofran, respectively), and Vitamin b2 and Zofran (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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