Vitamin b6 and Excedrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vitamin b6 (pyridoxine) and Excedrin (acetaminophen; aspirin; caffeine). Common drug interactions include hyperhidrosis among females and abdominal discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Vitamin b6 and Excedrin. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Vitamin b6?

Vitamin b6 has active ingredients of pyridoxine. It is often used in stress and anxiety. eHealthMe is studying from 16,183 Vitamin b6 users. Check the latest studies of Vitamin b6.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

On Jul, 16, 2026

53 people who take Vitamin b6 and Excedrin together, and have interactions are studied.

Vitamin b6 and Excedrin drug interactions.

What are the common drug interactions of Vitamin B6 and Excedrin, by gender? *:

female:

Hyperhidrosis (abnormally increased sweating)
Immunodeficiency
Inflammatory bowel disease
Influenza like illness
Lip swelling
Lupus-like syndrome (a disease symptom matches with lupus an immune disease)
Micturition disorder (disease of passing urine)
Muscle spasms (muscle contraction)
Myalgia (muscle pain)
Abdominal discomfort

male:

Abdominal discomfort
Constipation
Drug level decreased
Face oedema (swelling of face)
Gastritis (inflammation of stomach)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Injection site haemorrhage (bleeding from injection site)
Injection site pain
Laxative abuse
Muscle twitching

What are the common drug interactions of Vitamin B6 and Excedrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dysmenorrhoea (painful menstruation)
Haemorrhage (bleeding)
Herpes zoster
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Post herpetic neuralgia (neuralgia caused by the varicella zoster virus)
Uterine pain
Vomiting
Vulvovaginal dryness

30-39:

Anogenital warts
Blood hiv rna increased
Kidney infection
Renal failure (kidney dysfunction)
Viral load increased
Depression
Humerus fracture (injury to the upper arm bone)
Multiple fractures
Tooth loss
Upper limb fracture

40-49:

Wrist fracture
Therapeutic response unexpected
Essential tremor
Fibromyalgia (a long-term condition which causes pain all over the body)
Hypotension (abnormally low blood pressure)
Orthostatic intolerance (development of symptoms when standing upright which are relieved when sitting back down again)
Road traffic accident
Hypersensitivity
Nasopharyngitis (inflammation of the nasopharynx)
Pulmonary thrombosis (scarring in the lungs)

50-59:

Diarrhoea
Dizziness
Neuropathy peripheral (surface nerve damage)
Erythema (redness of the skin)
Oedema peripheral (superficial swelling)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Therapeutic response decreased (less preventive response)

60+:

Abdominal discomfort
Nausea (feeling of having an urge to vomit)
Intestinal obstruction
Malaise (a feeling of general discomfort or uneasiness)
Pain in extremity
Platelet count decreased
Pneumonia
Rhinorrhoea (watery mucus discharge from the nose)
Abdominal pain
Abdominal pain upper

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 19 people, 35.85%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 15 people, 28.30%
Migraine (headache): 6 people, 11.32%
Hiv Infection: 6 people, 11.32%
Diarrhea: 5 people, 9.43%
Multiple Myeloma (cancer of the plasma cells): 4 people, 7.55%
Nausea (feeling of having an urge to vomit): 3 people, 5.66%
Hypersensitivity: 3 people, 5.66%
High Blood Cholesterol: 3 people, 5.66%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

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