Vitamin d and Cotellic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vitamin d (ergocalciferol) and Cotellic (cobimetinib fumarate). Common drug interactions include blood alkaline phosphatase increased among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Vitamin d and Cotellic. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Vitamin d?

Vitamin d has active ingredients of ergocalciferol. It is often used in low vitamin d. eHealthMe is studying from 294,094 Vitamin d users. Check the latest studies of Vitamin d.

What is Cotellic?

Cotellic has active ingredients of cobimetinib fumarate. eHealthMe is studying from 1,908 Cotellic users. Check the latest studies of Cotellic.

On Jul, 05, 2026

19 people who take Vitamin d and Cotellic together, and have interactions are studied.

Vitamin d and Cotellic drug interactions.

What are the common drug interactions of Vitamin D and Cotellic, by gender? *:

female:

Blood alkaline phosphatase increased
Blood creatine phosphokinase increased
Diarrhoea
Malignant neoplasm progression (cancer tumour came back)
Plantar fasciitis (painful inflammatory process of the plantar fascia)
Rash
Renal failure (kidney dysfunction)
Nausea (feeling of having an urge to vomit)
Aphthous ulcer (mouth ulcer)
Gastric haemorrhage (bleeding stomach)

male:

Nausea (feeling of having an urge to vomit)
Anaemia (lack of blood)
Vomiting
Weight increased
Fatigue (feeling of tiredness)
Death
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Malignant neoplasm progression (cancer tumour came back)
Photosensitivity reaction

What are the common drug interactions of Vitamin D and Cotellic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Synovitis (inflammation of the synovial membrane)

40-49:

Hypoglycaemia (deficiency of glucose in the bloodstream)

50-59:

Anaemia (lack of blood)
Dehydration (dryness resulting from the removal of water)
Nausea (feeling of having an urge to vomit)
Photosensitivity reaction
Pneumonia
Vomiting
Weight increased

60+:

Diarrhoea
Malignant neoplasm progression (cancer tumour came back)
Gastric haemorrhage (bleeding stomach)
Haematemesis (vomiting of blood)
Hepatic cyst
Loss of consciousness
Renal haemorrhage (bleeding from kidney)
Retching (strong involuntary effort to vomit)
Ulcer
Ulcer haemorrhage (bleeding ulcer)

What are the existing conditions these people have? *

Malignant Melanoma (skin cancer rises from melancytes): 11 people, 57.89%
Thyroid Cancer: 2 people, 10.53%
Stress And Anxiety: 2 people, 10.53%
Ovarian Germ Cell Cancer: 2 people, 10.53%
Ovarian Cancer (cancer of ovary): 2 people, 10.53%
Nausea (feeling of having an urge to vomit): 2 people, 10.53%
Insomnia (sleeplessness): 2 people, 10.53%
Fever: 2 people, 10.53%
Neoplasm Malignant (cancer tumour): 1 person, 5.26%
Metastasis (spreadable cancer to other organ from origin): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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