Vivactil and Provera drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vivactil (protriptyline hydrochloride) and Provera (medroxyprogesterone acetate). Common drug interactions include blood cholesterol increased among females.

The phase IV clinical study analyzes what interactions people have when they take Vivactil and Provera. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Vivactil?

Vivactil has active ingredients of protriptyline hydrochloride. eHealthMe is studying from 386 Vivactil users. Check the latest studies of Vivactil.

What is Provera?

Provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 54,943 Provera users. Check the latest studies of Provera.



On Jul, 20, 2026

11 people who take Vivactil and Provera together, and have interactions are studied.

Vivactil and Provera drug interactions.

What are the common drug interactions of Vivactil and Provera, by gender? *:

female:

  1. Blood cholesterol increased
  2. Femur fracture
  3. Hand fracture
  4. Libido decreased (loss of interest in sex)
  5. Metrorrhagia (uterine bleeding at irregular intervals)
  6. Muscle spasms (muscle contraction)
  7. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
  8. Foot deformity (functional disability of foot)
  9. Abdominal pain upper
  10. Acute sinusitis

male:

n/a

What are the common drug interactions of Vivactil and Provera, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Blood cholesterol increased
  2. Femur fracture
  3. Hand fracture
  4. Libido decreased (loss of interest in sex)
  5. Metrorrhagia (uterine bleeding at irregular intervals)
  6. Muscle spasms (muscle contraction)
  7. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
  8. Foot deformity (functional disability of foot)
  9. Abdominal pain upper
  10. Acute sinusitis

60+:

n/a

What are the existing conditions these people have? *

  1. Osteoporosis (bones weak and more likely to break): 10 people, 90.91%
  2. Osteopenia (a condition where bone mineral density is lower than normal): 7 people, 63.64%
  3. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Vivactil and Provera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vivactil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Provera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Vivactil and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Provera and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on protriptyline hydrochloride and medroxyprogesterone acetate (the active ingredients of Vivactil and Provera, respectively), and Vivactil and Provera (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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