Vivelle-dot and Percocet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vivelle-dot (estradiol) and Percocet (acetaminophen; oxycodone hydrochloride). Common drug interactions include somnolence among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Vivelle-dot and Percocet. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Vivelle-dot?

Vivelle-dot has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 3,545 Vivelle-dot users. Check the latest studies of Vivelle-dot.

What is Percocet?

Percocet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 119,838 Percocet users. Check the latest studies of Percocet.

On Jul, 20, 2026

72 people who take Vivelle-dot and Percocet together, and have interactions are studied.

Vivelle-dot and Percocet drug interactions.

What are the common drug interactions of Vivelle-Dot and Percocet, by gender? *:

female:

Somnolence (a state of near-sleep, a strong desire for sleep)
Depression
Nausea (feeling of having an urge to vomit)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Fibula fracture
Anxiety
Chest pain
Foot deformity (functional disability of foot)
Gait disturbance
Injury

male:

Abdominal pain upper
Abscess (pus)
Bunion (a painful swelling on the first joint of the big toe)
Cancer pain
Cardiomegaly (increased size of heart than normal)
Cerebrovascular disorder (disease of brain)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Chest pain
Chondromalacia (anterior knee pain due to irritation of the cartilage on the under surface of the kneecap)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the common drug interactions of Vivelle-Dot and Percocet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain upper
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Nausea (feeling of having an urge to vomit)
Vomiting

30-39:

Arthralgia (joint pain)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscular weakness (muscle weakness)
Neuralgia (pain in one or more nerves)
Pain in extremity

40-49:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Embolic stroke (stroke due to obstruction due to an embolus)
Bipolar ii disorder (characterized by at least one episode of hypomania and at least one episode of major depression)
Drug ineffective
General physical health deterioration (weak health status)
Headache (pain in head)
Suicidal ideation
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Cutaneous lupus erythematosus (own immune system attacks various cells causing a wide variety of signs and symptoms)

50-59:

Abdominal pain upper
Aortic arteriosclerosis (hardening of the aortic arteries)
Laceration (tearing of soft body tissue)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Vision blurred
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Osteoporosis (bones weak and more likely to break)
Rash
Thoracic vertebral fracture
Fatigue (feeling of tiredness)

60+:

Nausea (feeling of having an urge to vomit)
Weight decreased
Dysgeusia (disorder of the sense of taste)
Dysstasia (difficulty in standing)
Fall
Feeling of body temperature change
Hearing impaired
Hot flush (sudden feelings of heat)
Influenza
Injection site haematoma (localized swelling filled with blood at injection site)

What are the existing conditions these people have? *

Bone Density Abnormal: 16 people, 22.22%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 12.50%
Insomnia (sleeplessness): 7 people, 9.72%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 9.72%
Osteoporosis (bones weak and more likely to break): 6 people, 8.33%
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 6 people, 8.33%
Migraine (headache): 5 people, 6.94%
Depression: 5 people, 6.94%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 5.56%
Immunodeficiency Common Variable: 4 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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