Vivelle and Actonel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vivelle (estradiol) and Actonel (risedronate sodium). Common drug interactions include breast cancer recurrent among females and memory impairment among males.

The phase IV clinical study analyzes what interactions people have when they take Vivelle and Actonel. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Vivelle?

Vivelle has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 6,624 Vivelle users. Check the latest studies of Vivelle.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

On Jul, 11, 2026

54 people who take Vivelle and Actonel together, and have interactions are studied.

What are the common drug interactions of Vivelle and Actonel, by gender? *:

female:

Breast cancer recurrent
Cerumen impaction
Dry mouth
Dysgeusia (disorder of the sense of taste)
Exostosis (formation of new bone on the surface of a bone)
Hip fracture
Oral torus (a lesion made of compact bone and occurs along the palate or the mandible inside the mouth)
Otitis externa (external ear infection)
Sialoadenitis (inflammation of a salivary gland)
Sinusitis (inflammation of sinus)

male:

Memory impairment
Micturition urgency (urgency to pass the urine)
Multiple fractures
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)

What are the common drug interactions of Vivelle and Actonel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anaemia (lack of blood)
Anxiety
Atrophy (wasting away of a part of the body)
Breast cancer
Diarrhoea
Drug hypersensitivity
Dyskinesia (abnormality or impairment of voluntary movement)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Intervertebral disc protrusion (spinal disc protrusion)
Mood swings (an extreme or rapid change in mood)

50-59:

Toothache (tooth pain)
Bruxism (habitual grinding of the teeth, typically during sleep)
Joint crepitation
Malocclusion (a misalignment)
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)
Herpes virus infection
Osteonecrosis (death of bone)
Vomiting
Alopecia (absence of hair from areas of the body)
Anoxic encephalopathy (brain damage due to lack of oxygen)

60+:

Tooth fracture
Dental caries
Oral torus (a lesion made of compact bone and occurs along the palate or the mandible inside the mouth)
Otitis externa (external ear infection)
Sialoadenitis (inflammation of a salivary gland)
Sinusitis (inflammation of sinus)
Tongue ulceration (ulcers on tongue)
Tooth deposit
Osteonecrosis of jaw (death of bone of jaw)
Oral disorder (mouth disease)

What are the existing conditions these people have? *

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 12 people, 22.22%
Osteopenia (a condition where bone mineral density is lower than normal): 6 people, 11.11%
Stress And Anxiety: 4 people, 7.41%
Insomnia (sleeplessness): 4 people, 7.41%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 5.56%
Immunodeficiency Common Variable: 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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