Vivelle and Lidoderm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vivelle (estradiol) and Lidoderm (lidocaine). Common drug interactions include impaired healing among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Vivelle and Lidoderm. It is created by eHealthMe based on reports of 87 people who take the same drugs from the FDA, and is updated regularly.

What is Vivelle?

Vivelle has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 6,624 Vivelle users. Check the latest studies of Vivelle.

What is Lidoderm?

Lidoderm has active ingredients of lidocaine. It is often used in pain. eHealthMe is studying from 10,524 Lidoderm users. Check the latest studies of Lidoderm.

On Aug, 03, 2026

87 people who take Vivelle and Lidoderm together, and have interactions are studied.

What are the common drug interactions of Vivelle and Lidoderm, by gender? *:

female:

Impaired healing
Influenza like illness
Oropharyngeal pain
Sinusitis (inflammation of sinus)
Skin lesion
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Chills (felling of cold)
Depression
Hyperhidrosis (abnormally increased sweating)

male:

Arthralgia (joint pain)
Depression
Fatigue (feeling of tiredness)
Haematuria (presence of blood in urine)
Hypersomnia (excessive daytime sleepiness (eds))
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Metastases to bone (cancer spreads to bone)
Metastases to skin (cancer spreads to skin)
Osteoporosis (bones weak and more likely to break)
Renal impairment (severely reduced kidney function)

What are the common drug interactions of Vivelle and Lidoderm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Accident
Affective disorder (mental disorder)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Anaemia (lack of blood)
Anxiety
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Aortic valve incompetence
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)

40-49:

Neuropathy peripheral (surface nerve damage)
Enchondroma (benign slow-growing tumour of cartilaginous cells at the ends of tubular bones)
Infarction (obstruction of the blood supply to an organ or region of tissue)
Joint effusion (presence of extra fluid in joint covering)
Joint stiffness
Ligament injury
Ligament rupture (tear in ligament)
Pain in extremity
Tendonitis (a condition that causes pain and swelling of tendons)
Arthralgia (joint pain)

50-59:

Asthenia (weakness)
Fall
Influenza like illness
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Neck pain
Oral infection
Sinusitis (inflammation of sinus)
Skin lesion
Stress
Chills (felling of cold)

60+:

Fatigue (feeling of tiredness)
Fall
Benign gastric neoplasm (benign (non-cancerous) tumours of the gastric)
Cataract (clouding of the lens inside the eye)
Haematuria (presence of blood in urine)
Hypersomnia (excessive daytime sleepiness (eds))
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Metastases to bone (cancer spreads to bone)
Metastases to skin (cancer spreads to skin)
Osteoporosis (bones weak and more likely to break)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 19 people, 21.84%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 9.20%
Sleep Disorder: 7 people, 8.05%
Insomnia (sleeplessness): 6 people, 6.90%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 6.90%
Depression: 6 people, 6.90%
Stress And Anxiety: 5 people, 5.75%
Primary Immunodeficiency Syndrome: 5 people, 5.75%
Osteoporosis (bones weak and more likely to break): 5 people, 5.75%
High Blood Pressure: 5 people, 5.75%

* Approximation only. Some reports may have incomplete information.

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