Vivelle and Phenergan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vivelle (estradiol) and Phenergan (promethazine hydrochloride). Common drug interactions include pain among females and infantile apnoeic attack among males.

The phase IV clinical study analyzes what interactions people have when they take Vivelle and Phenergan. It is created by eHealthMe based on reports of 89 people who take the same drugs from the FDA, and is updated regularly.

What is Vivelle?

Vivelle has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 6,624 Vivelle users. Check the latest studies of Vivelle.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

89 people who take Vivelle and Phenergan together, and have interactions are studied.

Vivelle and Phenergan drug interactions.

What are the common drug interactions of Vivelle and Phenergan, by gender? *:

female:

Pain
Chest pain
Anxiety
Dehydration (dryness resulting from the removal of water)
Back pain
Fatigue (feeling of tiredness)
Pyrexia (fever)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Muscle spasms (muscle contraction)
Abdominal pain upper

male:

Infantile apnoeic attack (episodes where breathing stops temporarily in infant)
Jaundice neonatal (yellowing of skin in neonate)
Premature baby
Basal ganglia haemorrhage (bleeding from blood vessels in an area of the brain responsible for body movements)
Talipes
Coagulation time prolonged
Laceration (tearing of soft body tissue)
Migraine (headache)
Premature delivery
Premature rupture of membranes

What are the common drug interactions of Vivelle and Phenergan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain upper
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)

30-39:

Migraine (headache)
Premature rupture of membranes
Abdominal pain
Chest pain
Cough
Abdominal pain upper
Decreased appetite
Diarrhoea
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Premature labour

40-49:

Dyspnoea (difficult or laboured respiration)
Pain
Arthralgia (joint pain)
Fall
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
Back pain
Blastomycosis (fungal infection caused by fungus blastomyces dermatitidis)
Cough

50-59:

Breast calcifications (deposits of calcium that can be seen on a mammogram of the breast)
Visual impairment
Cardiac failure congestive
Mitral valve incompetence (inefficient heart valve)
Oedema peripheral (superficial swelling)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Melaena (the passage of black, tarry stools)
Renal failure acute (rapid kidney dysfunction)
Surgery
Aortic valve incompetence

60+:

Abdominal pain
Bile duct stenosis (abnormal narrowing of the common bile duct)
Hypoacusis (loss of hearing)
Intestinal obstruction
Speech disorder
Abdominal distension
Erythema (redness of the skin)
Discomfort
Exposure to allergen
Abdominal pain upper

What are the existing conditions these people have? *

Pain: 16 people, 17.98%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 12 people, 13.48%
Breast Cancer Metastatic: 11 people, 12.36%
Depression: 11 people, 12.36%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 10.11%
High Blood Pressure: 9 people, 10.11%
Migraine (headache): 9 people, 10.11%
Hypersensitivity: 8 people, 8.99%
Stress And Anxiety: 8 people, 8.99%
Sinusitis (inflammation of sinus): 8 people, 8.99%

* Approximation only. Some reports may have incomplete information.

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