Voltaren and Endep drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Voltaren (diclofenac sodium) and Endep (amitriptyline hydrochloride). Common drug interactions include aneurysm among females and confusional state among males.

The phase IV clinical study analyzes what interactions people have when they take Voltaren and Endep. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Voltaren?

Voltaren has active ingredients of diclofenac sodium. It is often used in arthritis. eHealthMe is studying from 82,346 Voltaren users. Check the latest studies of Voltaren.

What is Endep?

Endep has active ingredients of amitriptyline hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 1,302 Endep users. Check the latest studies of Endep.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

13 people who take Voltaren and Endep together, and have interactions are studied.

What are the common drug interactions of Voltaren and Endep, by gender? *:

female:

Aneurysm (enlargement of an artery caused by a weakening of the artery wall)
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Drug ineffective
Electrocardiogram qt prolonged
Rectal haemorrhage (bleeding from anus)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Vulvovaginal candidiasis (vulvovaginal infection by fungi)

male:

Confusional state

What are the common drug interactions of Voltaren and Endep, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Vulvovaginal candidiasis (vulvovaginal infection by fungi)

40-49:

Aneurysm (enlargement of an artery caused by a weakening of the artery wall)
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Breast cancer
Drug ineffective
Electrocardiogram qt prolonged

50-59:

Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)

60+:

Rectal haemorrhage (bleeding from anus)

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 5 people, 38.46%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 23.08%
Pain: 3 people, 23.08%
Constipation: 3 people, 23.08%
Pulmonary Embolism (blockage of the main artery of the lung): 1 person, 7.69%
Multiple Myeloma (cancer of the plasma cells): 1 person, 7.69%
Concentric Sclerosis (tissue damage with ring formation): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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