Voltaren and Letairis drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Voltaren (diclofenac sodium) and Letairis (ambrisentan). Common drug interactions include cerebrovascular accident among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Voltaren and Letairis. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Voltaren?

Voltaren has active ingredients of diclofenac sodium. It is often used in arthritis. eHealthMe is studying from 82,346 Voltaren users. Check the latest studies of Voltaren.

What is Letairis?

Letairis has active ingredients of ambrisentan. It is often used in pulmonary hypertension. eHealthMe is studying from 94,041 Letairis users. Check the latest studies of Letairis.

On Jul, 25, 2026

51 people who take Voltaren and Letairis together, and have interactions are studied.

Voltaren and Letairis drug interactions.

What are the common drug interactions of Voltaren and Letairis, by gender? *:

female:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Crepitations (noises are produced by the rubbing of parts one against the other)
Dyspepsia (indigestion)
Ear pain
Facial paralysis (loss of function of face muscle)
Fall
Hypokinesia (decreased bodily movement)
Malaise (a feeling of general discomfort or uneasiness)
Neutropenia (an abnormally low number of neutrophils)
Oesophageal food impaction (blockage of oesophagus by food)

male:

Nausea (feeling of having an urge to vomit)
Vomiting
Arthralgia (joint pain)
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)
Chest pain
Injection site bruising
Mobility decreased (ability to move is reduced)
Weight decreased
Fluid retention (an abnormal accumulation of fluid in the blood)

What are the common drug interactions of Voltaren and Letairis, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain
Acute respiratory failure
Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back pain
Blood urea increased
Brain natriuretic peptide increased
Cardiac failure congestive
Cardiomegaly (increased size of heart than normal)

50-59:

Adjustment disorder with depressed mood
Adverse drug reaction
Anxiety
Arthralgia (joint pain)
Blood pressure increased
Body temperature increased
Diarrhoea
Drug ineffective
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)

60+:

Headache (pain in head)
Dyspnoea (difficult or laboured respiration)
Cardiac failure congestive
Malaise (a feeling of general discomfort or uneasiness)
Weight decreased
Abdominal discomfort
Angiopathy (generic term for a disease of the blood vessels)
Arthropathy
Back pain
Bone pain

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 39 people, 76.47%
Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 4 people, 7.84%

* Approximation only. Some reports may have incomplete information.

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