Voltaren and Sonata drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Voltaren (diclofenac sodium) and Sonata (zaleplon). Common drug interactions include hypoglycaemia among females and muscular weakness among males.

The phase IV clinical study analyzes what interactions people have when they take Voltaren and Sonata. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Voltaren?

Voltaren has active ingredients of diclofenac sodium. It is often used in arthritis. eHealthMe is studying from 82,346 Voltaren users. Check the latest studies of Voltaren.

What is Sonata?

Sonata has active ingredients of zaleplon. It is often used in insomnia. eHealthMe is studying from 3,330 Sonata users. Check the latest studies of Sonata.



On Jul, 27, 2026

46 people who take Voltaren and Sonata together, and have interactions are studied.

Voltaren and Sonata drug interactions.

What are the common drug interactions of Voltaren and Sonata, by gender? *:

female:

  1. Hypoglycaemia (deficiency of glucose in the bloodstream)
  2. Influenza like illness
  3. Lupus nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue)
  4. Memory impairment
  5. Oropharyngeal plaque (hard deposit on oropharynx)
  6. Staphylococcal infection (an infection with staphylococcus bacteria)
  7. Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
  8. Throat irritation
  9. Upper respiratory tract infection
  10. Back pain

male:

  1. Muscular weakness (muscle weakness)
  2. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  3. Blindness
  4. Blood glucose increased
  5. Blood triglycerides increased
  6. Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
  7. Change of bowel habit
  8. Colitis (inflammation of colon)
  9. Compartment syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels)
  10. Contusion (a type of hematoma of tissue in which capillaries)

What are the common drug interactions of Voltaren and Sonata, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Chronic kidney disease

30-39:

  1. Abdominal pain upper
  2. Back injury
  3. Depression
  4. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  5. Diabetes mellitus inadequate control
  6. Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
  7. Dizziness
  8. Feeding disorder (when children refuse to eat certain food groups)
  9. Injection site bruising
  10. Injection site pain

40-49:

n/a

50-59:

  1. Abdominal pain
  2. Alanine aminotransferase increased
  3. Anaemia (lack of blood)
  4. Angina pectoris (chest pain due to ischemia of the heart muscle)
  5. Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
  6. Blood lactate dehydrogenase increased
  7. Cardiac murmur (an heart sound in valve abnormality)
  8. Carotid bruit (sound heard over the carotid artery area during auscultation)
  9. Cerebrovascular stenosis (narrowing of brain blood vessels)
  10. Malaise (a feeling of general discomfort or uneasiness)

60+:

  1. Arthralgia (joint pain)
  2. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  3. Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
  4. Drug eruption (adverse drug reaction of the skin)
  5. Medial tibial stress syndrome (pain in medial part of tibia)
  6. Muscular weakness (muscle weakness)
  7. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  8. Pain in extremity
  9. Sudden death

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 21 people, 45.65%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 19.57%
  3. Stress And Anxiety: 5 people, 10.87%
  4. Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 10.87%
  5. Pain: 4 people, 8.70%
  6. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 8.70%

* Approximation only. Some reports may have incomplete information.

Do you take Voltaren and Sonata?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Voltaren and Sonata:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Voltaren:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Sonata:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Voltaren and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Sonata and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on diclofenac sodium and zaleplon (the active ingredients of Voltaren and Sonata, respectively), and Voltaren and Sonata (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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