Votrient and Coumadin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Votrient (pazopanib hydrochloride) and Coumadin (warfarin sodium). Common drug interactions include abdominal pain among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Votrient and Coumadin. It is created by eHealthMe based on reports of 85 people who take the same drugs from the FDA, and is updated regularly.

What is Votrient?

Votrient has active ingredients of pazopanib hydrochloride. It is often used in metastatic renal cell carcinoma. eHealthMe is studying from 25,347 Votrient users. Check the latest studies of Votrient.

What is Coumadin?

Coumadin has active ingredients of warfarin sodium. It is often used in blood clots. eHealthMe is studying from 133,228 Coumadin users. Check the latest studies of Coumadin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

85 people who take Votrient and Coumadin together, and have interactions are studied.

Votrient and Coumadin drug interactions.

What are the common drug interactions of Votrient and Coumadin, by gender? *:

female:

Abdominal pain
International normalised ratio increased
Anxiety
Blood creatinine increased
Cardiac failure congestive
Cardiomyopathy (weakening of the heart muscle)
Cerebral haemorrhage (bleeding within the brain)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dyspnoea (difficult or laboured respiration)
Haemorrhage intracranial (bleeding within the skull)

male:

Nausea (feeling of having an urge to vomit)
Vomiting
Dyspnoea (difficult or laboured respiration)
Haematuria (presence of blood in urine)
Thrombosis (formation of a blood clot inside a blood vessel)
Activities of daily living impaired
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Renal cancer (cancer of kidney)
Abdominal discomfort

What are the common drug interactions of Votrient and Coumadin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Death
Metastases to central nervous system (cancer spreads to central nervous system)
Rash
Urinary tract infection

50-59:

Fatigue (feeling of tiredness)
Hypertension (high blood pressure)
Nausea (feeling of having an urge to vomit)
Death
Drug ineffective
Haematemesis (vomiting of blood)
Haematuria (presence of blood in urine)
International normalised ratio increased
Muscle spasms (muscle contraction)
Surgery

60+:

Nausea (feeling of having an urge to vomit)
Diarrhoea
Pneumonia
Abdominal discomfort
Activities of daily living impaired
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Muscle spasms (muscle contraction)
Pulmonary embolism (blockage of the main artery of the lung)
Renal cancer (cancer of kidney)

What are the existing conditions these people have? *

Renal Cell Carcinoma (a kidney cancer): 43 people, 50.59%

* Approximation only. Some reports may have incomplete information.

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