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Votrient and Milk thistle drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Votrient (pazopanib hydrochloride) and Milk thistle (milk thistle). Common drug interactions include constipation among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Votrient and Milk thistle. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Votrient?

Votrient has active ingredients of pazopanib hydrochloride. It is often used in metastatic renal cell carcinoma. eHealthMe is studying from 25,347 Votrient users. Check the latest studies of Votrient.

What is Milk thistle?

Milk thistle has active ingredients of milk thistle. It is often used in fatty liver. eHealthMe is studying from 5,057 Milk thistle users. Check the latest studies of Milk thistle.

On Jul, 15, 2026

17 people who take Votrient and Milk thistle together, and have interactions are studied.

Votrient and Milk thistle drug interactions.

What are the common drug interactions of Votrient and Milk Thistle, by gender? *:

female:

  1. Constipation

male:

  1. Diarrhoea
  2. Fatigue (feeling of tiredness)
  3. Nausea (feeling of having an urge to vomit)
  4. Arthralgia (joint pain)
  5. Localised infection (infection at the single location)
  6. Depression
  7. Pain
  8. Angiosarcoma (cancer of endothelial-type cells that line vessel walls)
  9. Death
  10. Decreased appetite

What are the common drug interactions of Votrient and Milk Thistle, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Cough
  2. Dyspnoea (difficult or laboured respiration)
  3. Decreased appetite
  4. Diarrhoea
  5. Neoplasm progression (growth of tumour)
  6. Weight decreased
  7. Liver injury
  8. Nausea (feeling of having an urge to vomit)
  9. Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)
  10. Constipation

What are the existing conditions these people have? *

  1. Renal Cell Carcinoma (a kidney cancer): 7 people, 41.18%
  2. Rhabdomyosarcoma (cancer of the bone, soft tissues, or connective tissue (e.g., tendon or cartilage)): 2 people, 11.76%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 11.76%
  4. Depression: 2 people, 11.76%
  5. Cancer Pain: 2 people, 11.76%
  6. Skin Cancer: 1 person, 5.88%
  7. Pain: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Votrient and Milk thistle?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Votrient and Milk thistle:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Votrient:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Milk thistle:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Votrient and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Milk thistle and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on pazopanib hydrochloride and milk thistle (the active ingredients of Votrient and Milk thistle, respectively), and Votrient and Milk thistle (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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