Votrient and Topotecan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Votrient (pazopanib hydrochloride) and Topotecan (topotecan hydrochloride). Common drug interactions include pulmonary embolism among females and neoplasm recurrence among males.

The phase IV clinical study analyzes what interactions people have when they take Votrient and Topotecan. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Votrient?

Votrient has active ingredients of pazopanib hydrochloride. It is often used in metastatic renal cell carcinoma. eHealthMe is studying from 25,347 Votrient users. Check the latest studies of Votrient.

What is Topotecan?

Topotecan has active ingredients of topotecan hydrochloride. eHealthMe is studying from 5,853 Topotecan users. Check the latest studies of Topotecan.

On Jul, 18, 2026

38 people who take Votrient and Topotecan together, and have interactions are studied.

Votrient and Topotecan drug interactions.

What are the common drug interactions of Votrient and Topotecan, by gender? *:

female:

Pulmonary embolism (blockage of the main artery of the lung)
Dehydration (dryness resulting from the removal of water)
Haemolytic uraemic syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased
Mucosal inflammation (infection of mucous membrane)
Nausea (feeling of having an urge to vomit)
Pain
Periodontal disease (disease that attacks the gum and bone and around the teeth)
Vomiting

male:

Neoplasm recurrence (reoccurrence of tumour)
Malignant neoplasm progression (cancer tumour came back)
Dysuria (painful or difficult urination)
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Thrombocytopenia (decrease of platelets in blood)
Urinary tract infection
Dehydration (dryness resulting from the removal of water)
Pneumonia
Syncope (loss of consciousness with an inability to maintain postural tone)
Alanine aminotransferase increased

What are the common drug interactions of Votrient and Topotecan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Mucosal inflammation (infection of mucous membrane)
Periodontal disease (disease that attacks the gum and bone and around the teeth)
Abdominal pain

20-29:

Neoplasm recurrence (reoccurrence of tumour)
Malignant neoplasm progression (cancer tumour came back)
Neoplasm progression (growth of tumour)
Metastases to liver (cancer spreads to liver)
Metastases to lymph nodes (cancer spreads to lymph node)
Bacteraemia (presence of bacteria in the blood)
Febrile neutropenia (fever with reduced white blood cells)

30-39:

n/a

40-49:

Renal failure acute (rapid kidney dysfunction)

50-59:

Haemolytic uraemic syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more)
Dehydration (dryness resulting from the removal of water)
Syncope (loss of consciousness with an inability to maintain postural tone)
Abdominal distension
Abdominal pain
Asthenia (weakness)
Death
Dysuria (painful or difficult urination)

60+:

Pulmonary embolism (blockage of the main artery of the lung)
Abdominal pain
Urinary tract infection
Nausea (feeling of having an urge to vomit)
Pain
Pneumonia
Vomiting
Abdominal abscess (collection of pus in abdomen)
Alanine aminotransferase increased
Aspartate aminotransferase increased

What are the existing conditions these people have? *

Undifferentiated Sarcoma (undifferentiated cancer): 17 people, 44.74%
Neoplasm Recurrence (reoccurrence of tumour): 17 people, 44.74%
Metastases To Pancreas (cancer spreads to pancreas): 17 people, 44.74%
Rhabdomyosarcoma (cancer of the bone, soft tissues, or connective tissue (e.g., tendon or cartilage)): 9 people, 23.68%
High Blood Pressure: 6 people, 15.79%
Tumor: 5 people, 13.16%
Pain: 3 people, 7.89%
Depression: 3 people, 7.89%
Synovial Sarcoma (tumour of synovial membrane of joint): 2 people, 5.26%
Osteoporosis (bones weak and more likely to break): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Votrient and Topotecan?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously