Vraylar and Ativan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vraylar (cariprazine hydrochloride) and Ativan (lorazepam). Common drug interactions include heart rate increased among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Vraylar and Ativan. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Vraylar?

Vraylar has active ingredients of cariprazine hydrochloride. eHealthMe is studying from 6,136 Vraylar users. Check the latest studies of Vraylar.

What is Ativan?

Ativan has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 78,506 Ativan users. Check the latest studies of Ativan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

66 people who take Vraylar and Ativan together, and have interactions are studied.

What are the common drug interactions of Vraylar and Ativan, by gender? *:

female:

Heart rate increased
Hypertension (high blood pressure)
Irritability
Night sweats (sweating in night)
Petit mal epilepsy (absence seizure)
Pregnancy
Restless legs syndrome (a powerful urge to move your legs)
Suicide attempt
Abdominal pain upper
Arthralgia (joint pain)

male:

Drug ineffective
Bipolar disorder (mood disorder)
Drooling (drop saliva uncontrollably from the mouth)
Eating disorder
Exostosis (formation of new bone on the surface of a bone)
Eye movement disorder
Gait disturbance
Gastric disorder (disease of stomach)
Heart rate increased
Hospitalisation

What are the common drug interactions of Vraylar and Ativan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups)

20-29:

Gastrointestinal disorder (functional problems of gastrointestinal tract)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Muscle spasms (muscle contraction)
Overdose
Rash macular (small, flat red spots)
Somnolence (a state of near-sleep, a strong desire for sleep)
Bipolar disorder (mood disorder)
Blood prolactin increased
Blood testosterone decreased

30-39:

Rash pruritic (redness with itching)
Tardive dyskinesia (a disorder that involves involuntary movements)
Dyskinesia (abnormality or impairment of voluntary movement)
Cough
Injection site erythema (redness at injection site)
Injection site mass
Injection site pain
Injection site rash
Pyrexia (fever)
Viral infection

40-49:

Arthralgia (joint pain)
Dysphagia (a condition in which swallowing is difficult or painful)
Fatigue (feeling of tiredness)
Infectious mononucleosis (infection usually caused by the epstein-barr virus)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)

50-59:

Somnolence (a state of near-sleep, a strong desire for sleep)
Drug ineffective
Therapeutic response unexpected
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Eye pain
Hypoaesthesia (reduced sense of touch or sensation)
Nicotine dependence
Ocular discomfort (a generic expression when there is lack of ease in/about the eyes)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Rash pruritic (redness with itching)

60+:

Bruxism (habitual grinding of the teeth, typically during sleep)
Dry mouth
Dysstasia (difficulty in standing)
Gait disturbance
Gastrointestinal oedema (excessive build-up of fluid in the gastrointestinal tract tissues)
Hypophagia (reduced food intake)
Intestinal obstruction
Night sweats (sweating in night)
Sleep disorder
Abdominal pain upper

What are the existing conditions these people have? *

Depression: 11 people, 16.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 13.64%
Bipolar Disorder (mood disorder): 8 people, 12.12%
Tardive Dyskinesia (a disorder that involves involuntary movements): 7 people, 10.61%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 10.61%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 6 people, 9.09%
Insomnia (sleeplessness): 6 people, 9.09%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 6 people, 9.09%
Asthma: 5 people, 7.58%
Sleep Disorder: 4 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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