Vumerity and Savella drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vumerity (diroximel fumarate) and Savella (milnacipran hydrochloride). Common drug interactions include asthenia among females and cardiac failure among males.

The phase IV clinical study analyzes what interactions people have when they take Vumerity and Savella. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Vumerity?

Vumerity has active ingredients of diroximel fumarate. eHealthMe is studying from 9,781 Vumerity users. Check the latest studies of Vumerity.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

11 people who take Vumerity and Savella together, and have interactions are studied.

What are the common drug interactions of Vumerity and Savella, by gender? *:

female:

Asthenia (weakness)
Contusion (a type of hematoma of tissue in which capillaries)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Dyspnoea exertional (breathlessness or shortness of breath)
Flushing (the warm, red condition of human skin)
Pain in extremity
Peripheral swelling
Type 2 diabetes mellitus
Sensory disturbance (sense disturbance)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

male:

Cardiac failure
Infrequent bowel movements
Intervertebral disc disorder (spinal disc disorder)

What are the common drug interactions of Vumerity and Savella, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Fall
Muscular weakness (muscle weakness)
Sensory disturbance (sense disturbance)

60+:

Asthenia (weakness)
Blood glucose decreased
Pain in extremity
Peripheral swelling
Pruritus (severe itching of the skin)
Type 2 diabetes mellitus
Vomiting
Cardiac failure
Infrequent bowel movements
Intervertebral disc disorder (spinal disc disorder)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 11 people, 100.00%
Hypersensitivity: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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