Vyvanse and Adderall 5 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vyvanse (lisdexamfetamine dimesylate) and Adderall 5 (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate). Common drug interactions include abdominal pain among females and dystonia among males.

The phase IV clinical study analyzes what interactions people have when they take Vyvanse and Adderall 5. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,868 Vyvanse users. Check the latest studies of Vyvanse.

What is Adderall 5?

Adderall 5 has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 2,997 Adderall 5 users. Check the latest studies of Adderall 5.

On Jul, 27, 2026

17 people who take Vyvanse and Adderall 5 together, and have interactions are studied.

Vyvanse and Adderall 5 drug interactions.

What are the common drug interactions of Vyvanse and Adderall 5, by gender? *:

female:

Abdominal pain
Anxiety
Dizziness
Gastritis (inflammation of stomach)
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Dehydration (dryness resulting from the removal of water)
Hypokalaemia (low potassium)
Lethargy (tiredness)

male:

Dystonia (abnormal muscle tone)
Abnormal dreams
Agitation (state of anxiety or nervous excitement)
Flushing (the warm, red condition of human skin)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Homicidal ideation (thoughts about human killing another human)
Hot flush (sudden feelings of heat)
Pain of skin
Suicidal ideation

What are the common drug interactions of Vyvanse and Adderall 5, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Dystonia (abnormal muscle tone)
Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dermatillomania (skin picking disorders)
Emotional disorder
Emotional distress
Fear
General physical health deterioration (weak health status)

10-19:

Somnolence (a state of near-sleep, a strong desire for sleep)
Suicidal ideation
Abnormal behaviour
Dyspnoea (difficult or laboured respiration)
Insomnia (sleeplessness)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)

20-29:

Menstruation irregular
Aggression
Agitation (state of anxiety or nervous excitement)
Drug dependence
Physical abuse
Verbal abuse (abusive behaviour involving the use of language)

30-39:

Palpitations (feelings or sensations that your heart is pounding or racing)
Dehydration (dryness resulting from the removal of water)
Dizziness
Gastritis (inflammation of stomach)
Hypokalaemia (low potassium)
Lethargy (tiredness)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Oesophagitis (inflammation of oesophagus)

40-49:

Acne (skin problems that cause pimples)
Agitation (state of anxiety or nervous excitement)
Anger
Anxiety
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug ineffective
Hearing impaired
Mood swings (an extreme or rapid change in mood)
Muscle tightness
Palpitations (feelings or sensations that your heart is pounding or racing)

50-59:

Abdominal pain
Anaemia (lack of blood)
Disturbance in attention
Dizziness
Dyspepsia (indigestion)
Epicondylitis (tennis elbow)
Gastritis (inflammation of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hepatitis b

60+:

n/a

What are the existing conditions these people have? *

Oesophagitis (inflammation of oesophagus): 2 people, 11.76%
Bipolar Disorder (mood disorder): 2 people, 11.76%
Sleep Disorder: 1 person, 5.88%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 5.88%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 5.88%
Mood Swings (an extreme or rapid change in mood): 1 person, 5.88%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 5.88%
Low Density Lipoprotein Increased (cholesterol increased in blood): 1 person, 5.88%
Fatigue (feeling of tiredness): 1 person, 5.88%
Drowsiness: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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