Vyvanse and Amphetamine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vyvanse (lisdexamfetamine dimesylate) and Amphetamine (amphetamine). Common drug interactions include fatigue among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Vyvanse and Amphetamine. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,868 Vyvanse users. Check the latest studies of Vyvanse.

What is Amphetamine?

Amphetamine has active ingredients of amphetamine. eHealthMe is studying from 980 Amphetamine users. Check the latest studies of Amphetamine.

On Jul, 19, 2026

20 people who take Vyvanse and Amphetamine together, and have interactions are studied.

Vyvanse and Amphetamine drug interactions.

What are the common drug interactions of Vyvanse and Amphetamine, by gender? *:

female:

Fatigue (feeling of tiredness)
Memory impairment
Sleep disorder
Abortion spontaneous (naturally occurring miscarriage)
Blood insulin increased
Blood iron decreased
Drug dependence
Gestational diabetes (diabetes in pregnancy)
Hypersomnia (excessive daytime sleepiness (eds))
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

male:

Drug ineffective
Disturbance in attention
Acne (skin problems that cause pimples)
Apathy
Asthenia (weakness)
Depressed mood
Erythema (redness of the skin)
Eyelid skin dryness
Hordeolum (small collection of pus (abscess) on the eyelid)

What are the common drug interactions of Vyvanse and Amphetamine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Apathy
Asthenia (weakness)
Depressed mood
Obstructive sleep apnoea syndrome (frequent pauses in breathing during sleep usually accompanied by loud snoring)
Rash
Weight decreased

20-29:

Asthma
Disturbance in attention
Drug ineffective
Fatigue (feeling of tiredness)
Infection
Lethargy (tiredness)
Memory impairment
Nasopharyngitis (inflammation of the nasopharynx)
Sleep disorder due to a general medical condition
Therapeutic response decreased (less preventive response)

30-39:

Drug ineffective
Disturbance in attention
Hypersomnia (excessive daytime sleepiness (eds))
Antinuclear antibody positive
Arthralgia (joint pain)
Blepharospasm (any abnormal contraction or twitch of the eyelid)
Blood pressure increased
Chest pain
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Family stress

40-49:

Anal abscess
Cellulitis (infection under the skin)
Cellulitis gangrenous (localized inflammation of the soft or connective tissue with considerable mass of body tissue dies (necrosis))
Gangrene (body tissue dies)
Genital abscess (build up of pus in genital)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Perineal abscess
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Vulval abscess

50-59:

Sleep disorder
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Balance disorder
Contusion (a type of hematoma of tissue in which capillaries)
Dysstasia (difficulty in standing)
Fall
Fatigue (feeling of tiredness)
Gait disturbance
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Speech disorder

60+:

n/a

What are the existing conditions these people have? *

High Blood Pressure: 2 people, 10.00%
Drowsiness: 2 people, 10.00%
Asthma: 2 people, 10.00%
Bipolar Disorder (mood disorder): 2 people, 10.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 10.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 10.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 10.00%
Alcoholism (problems with alcohol): 1 person, 5.00%
Binge Eating (pattern of disordered eating which consists of episodes of uncontrollable eating): 1 person, 5.00%
Depression: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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