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Vyvanse and Amrix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vyvanse (lisdexamfetamine dimesylate) and Amrix (cyclobenzaprine hydrochloride). Common drug interactions include dry throat among females and balance disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Vyvanse and Amrix. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,868 Vyvanse users. Check the latest studies of Vyvanse.

What is Amrix?

Amrix has active ingredients of cyclobenzaprine hydrochloride. It is often used in back pain. eHealthMe is studying from 1,130 Amrix users. Check the latest studies of Amrix.

On Jul, 19, 2026

21 people who take Vyvanse and Amrix together, and have interactions are studied.

Vyvanse and Amrix drug interactions.

What are the common drug interactions of Vyvanse and Amrix, by gender? *:

female:

  1. Dry throat
  2. Memory impairment
  3. Post-traumatic stress disorder
  4. Throat irritation
  5. Upper-airway cough syndrome
  6. Uterine haemorrhage (uterine bleeding)
  7. Bruxism (habitual grinding of the teeth, typically during sleep)
  8. Headache (pain in head)
  9. Nightmare (unpleasant dream)
  10. Tooth disorder (tooth disease)

male:

  1. Balance disorder
  2. Bruxism (habitual grinding of the teeth, typically during sleep)
  3. Tooth infection
  4. Toothache (tooth pain)
  5. Blood pressure increased
  6. Fall
  7. Abdominal pain lower
  8. Accident
  9. Cataract (clouding of the lens inside the eye)
  10. Folliculitis (infection of hair root)

What are the common drug interactions of Vyvanse and Amrix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Lacrimation increased
  2. Neutropenia (an abnormally low number of neutrophils)

50-59:

n/a

60+:

  1. Balance disorder
  2. Bruxism (habitual grinding of the teeth, typically during sleep)
  3. Tooth infection
  4. Toothache (tooth pain)
  5. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  6. Fall
  7. Muscle spasms (muscle contraction)
  8. Muscle tightness
  9. Dementia (madness)
  10. Dental caries

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 17 people, 80.95%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 52.38%
  3. Nightmares (unpleasant dreams): 5 people, 23.81%
  4. Drowsiness: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Vyvanse and Amrix?

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- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Vyvanse and Amrix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vyvanse:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Amrix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Vyvanse and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Amrix and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on lisdexamfetamine dimesylate and cyclobenzaprine hydrochloride (the active ingredients of Vyvanse and Amrix, respectively), and Vyvanse and Amrix (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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