Vyvanse and Aricept drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vyvanse (lisdexamfetamine dimesylate) and Aricept (donepezil hydrochloride). Common drug interactions include hiatus hernia among females and myelopathy among males.

The phase IV clinical study analyzes what interactions people have when they take Vyvanse and Aricept. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,868 Vyvanse users. Check the latest studies of Vyvanse.

What is Aricept?

Aricept has active ingredients of donepezil hydrochloride. It is often used in alzheimer's disease. eHealthMe is studying from 24,756 Aricept users. Check the latest studies of Aricept.

On Jul, 11, 2026

56 people who take Vyvanse and Aricept together, and have interactions are studied.

What are the common drug interactions of Vyvanse and Aricept, by gender? *:

female:

Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hypercapnia (too much smoke)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Immune system disorder
Loss of consciousness
Fall
Productive cough
Dyspnoea (difficult or laboured respiration)
Respiratory tract infection
Sinusitis (inflammation of sinus)

male:

Myelopathy (any neurologic deficit related to the spinal cord)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Drug ineffective
Dry skin
Fatigue (feeling of tiredness)
General symptom
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nephrolithiasis (calculi in the kidneys)
Neuralgia (pain in one or more nerves)
Optic neuritis (optic nerve inflammation)

What are the common drug interactions of Vyvanse and Aricept, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Suicidal ideation
Abdominal discomfort
Anger
Anxiety
Depressed mood
Headache (pain in head)
Migraine (headache)

20-29:

n/a

30-39:

n/a

40-49:

Alopecia (absence of hair from areas of the body)
Hair colour changes
Hair disorder

50-59:

Fall
Initial insomnia (feeling of inadequate or poor-quality sleep)
Stress
Renal failure (kidney dysfunction)
Chronic kidney disease
Dehydration (dryness resulting from the removal of water)
Drug ineffective
Nephrolithiasis (calculi in the kidneys)
Urinary tract infection

60+:

Productive cough
Dyspnoea (difficult or laboured respiration)
Pneumonia
Psoriasis (immune-mediated disease that affects the skin)
Allergy to arthropod bite
Anxiety
Back pain
Blood pressure increased
Cataract (clouding of the lens inside the eye)
Chest pain

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 22 people, 39.29%
Insomnia (sleeplessness): 13 people, 23.21%
High Blood Pressure: 12 people, 21.43%
Pain: 11 people, 19.64%
Sleep Disorder: 10 people, 17.86%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 10 people, 17.86%
Nausea (feeling of having an urge to vomit): 10 people, 17.86%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 16.07%
Diarrhea: 8 people, 14.29%
Cardiac Disorder: 8 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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