Vyvanse and Brexpiprazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vyvanse (lisdexamfetamine dimesylate) and Brexpiprazole (brexpiprazole). Common drug interactions include fatigue among females and agitation among males.

The phase IV clinical study analyzes what interactions people have when they take Vyvanse and Brexpiprazole. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,872 Vyvanse users. Check the latest studies of Vyvanse.

What is Brexpiprazole?

Brexpiprazole has active ingredients of brexpiprazole. eHealthMe is studying from 1,164 Brexpiprazole users. Check the latest studies of Brexpiprazole.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

13 people who take Vyvanse and Brexpiprazole together, and have interactions are studied.

Vyvanse and Brexpiprazole drug interactions.

What are the common drug interactions of Vyvanse and Brexpiprazole, by gender? *:

female:

Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Restlessness (not able to rest)
Anxiety
Decreased interest
Depressed mood
Somnolence (a state of near-sleep, a strong desire for sleep)
Weight increased
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Cough

male:

Agitation (state of anxiety or nervous excitement)
Antisocial behaviour
Headache (pain in head)
Antidepressant drug level below therapeutic
Arthralgia (joint pain)
Death
Hunger
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Weight increased

What are the common drug interactions of Vyvanse and Brexpiprazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Agitation (state of anxiety or nervous excitement)
Antisocial behaviour

20-29:

Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Cough
Fatigue (feeling of tiredness)
Growing pains (child sometimes wake up crying in the middle of the night complaining of throbbing leg pain)
Hypersensitivity
Insomnia (sleeplessness)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Nasopharyngitis (inflammation of the nasopharynx)
Pneumonia
Restlessness (not able to rest)

30-39:

n/a

40-49:

Anxiety
Decreased interest
Depressed mood
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Restlessness (not able to rest)
Somnolence (a state of near-sleep, a strong desire for sleep)
Weight increased
Antidepressant drug level below therapeutic
Arthralgia (joint pain)

50-59:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Fall
Death
Headache (pain in head)
Infusion related reaction
Pain
Red blood cell sedimentation rate increased
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Weight bearing difficulty (difficulty due to weight of thigh fat deposition)
Fatigue (feeling of tiredness)

60+:

n/a

What are the existing conditions these people have? *

Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 5 people, 38.46%
Stress And Anxiety: 4 people, 30.77%
Mood Swings (an extreme or rapid change in mood): 2 people, 15.38%
Immunodeficiency Common Variable: 2 people, 15.38%
Depression: 2 people, 15.38%
Trichotillomania (the compulsive urge to pull out (and in some cases, eat) one's own hair leading to noticeable hair loss, distress): 1 person, 7.69%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 7.69%
Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 1 person, 7.69%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 7.69%
Movement - Uncontrolled Or Slow: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Vyvanse and Brexpiprazole?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously