Vyvanse and Esgic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vyvanse (lisdexamfetamine dimesylate) and Esgic (acetaminophen; butalbital; caffeine). Common drug interactions include pain among females and clavicle fracture among males.

The phase IV clinical study analyzes what interactions people have when they take Vyvanse and Esgic. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,868 Vyvanse users. Check the latest studies of Vyvanse.

What is Esgic?

Esgic has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 882 Esgic users. Check the latest studies of Esgic.

On Jul, 15, 2026

21 people who take Vyvanse and Esgic together, and have interactions are studied.

What are the common drug interactions of Vyvanse and Esgic, by gender? *:

female:

Pain
Somnolence (a state of near-sleep, a strong desire for sleep)
Abdominal discomfort
Abdominal pain
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bronchial hyperreactivity
Bruxism (habitual grinding of the teeth, typically during sleep)
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)
Fibromyalgia (a long-term condition which causes pain all over the body)
Hepatic mass

male:

Clavicle fracture
Contusion (a type of hematoma of tissue in which capillaries)
Somnolence (a state of near-sleep, a strong desire for sleep)
Visual impairment
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Road traffic accident
Acarodermatitis (skin inflammation caused by mites (acarids))
Corneal thinning
Dehydration (dryness resulting from the removal of water)
Disability

What are the common drug interactions of Vyvanse and Esgic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal discomfort
Drug effect decreased
Urticaria (rash of round, red welts on the skin that itch intensely)
Heart rate increased
Increased appetite
Insomnia (sleeplessness)
Lethargy (tiredness)
Pain
Scar
Skin ulcer haemorrhage (bleeding skin ulcer)

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 42.86%
Insomnia (sleeplessness): 7 people, 33.33%
Nausea (feeling of having an urge to vomit): 2 people, 9.52%
Muscle Aches (muscle pain): 2 people, 9.52%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 2 people, 9.52%
Chest Pain: 2 people, 9.52%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 9.52%
Acne (skin problems that cause pimples): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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