Vyvanse and Fetzima drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vyvanse (lisdexamfetamine dimesylate) and Fetzima (levomilnacipran hydrochloride). Common drug interactions include abnormal behaviour among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Vyvanse and Fetzima. It is created by eHealthMe based on reports of 85 people who take the same drugs from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,868 Vyvanse users. Check the latest studies of Vyvanse.

What is Fetzima?

Fetzima has active ingredients of levomilnacipran hydrochloride. It is often used in depression. eHealthMe is studying from 2,077 Fetzima users. Check the latest studies of Fetzima.

On Jul, 20, 2026

85 people who take Vyvanse and Fetzima together, and have interactions are studied.

What are the common drug interactions of Vyvanse and Fetzima, by gender? *:

female:

Abnormal behaviour
Anger
Blindness
Blood potassium decreased
Blood pressure increased
Central pain syndrome (neurological condition caused by damage or malfunction in the central nervous system)
Coeliac disease (simple food intolerance)
Decreased appetite
Hospitalisation
Insomnia (sleeplessness)

male:

Fatigue (feeling of tiredness)
Pain
Psychomotor hyperactivity (feelings of extreme restlessness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Therapeutic response unexpected
Weight decreased
Malaise (a feeling of general discomfort or uneasiness)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Hypnopompic hallucination
Abdominal discomfort

What are the common drug interactions of Vyvanse and Fetzima, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Panic disorder
Post concussion syndrome
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sleep inertia (feeling of grogginess and disorientation that can come with awakening from a deep sleep)
Sleep paralysis (waking up and unable to move or speak)
Thirst
Weight decreased
Bedridden
Fibromuscular dysplasia (abnormal cellular growth in the walls of medium and large arteries)
Headache (pain in head)

30-39:

Suicidal ideation
Anxiety
Blood triglycerides increased
Disability
Intertrigo (inflammation (rash) of the body folds (adjacent areas of skin))
Long qt syndrome (disorder of the heart's electrical system)
Lumbar radiculopathy (radicular pain in the low back and legs)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Obesity (having too much body fat)
Pain in extremity

40-49:

Dizziness
Blindness
Joint swelling
Dry mouth
Dyspnoea (difficult or laboured respiration)
Glossodynia (a burning or painful sensation in the tongue)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pruritus (severe itching of the skin)
Tongue discolouration (colour change of tongue)
Weight increased

50-59:

Inflammation
Intervertebral disc protrusion (spinal disc protrusion)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Vertigo
Back pain
Generalised anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry)
Headache (pain in head)
Hypersensitivity
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Pain

60+:

Hallucination, visual (seeing things that aren't there)
Hyperglycaemia (high blood sugar)
Hyperlipidaemia (presence of excess lipids in the blood)
Periodic limb movement disorder
Pneumonia
Urinary tract infection
Weight increased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 61 people, 71.76%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 37 people, 43.53%
Drowsiness: 14 people, 16.47%
Stress And Anxiety: 5 people, 5.88%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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