Vyvanse and Folate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vyvanse (lisdexamfetamine dimesylate) and Folate (folic acid). Common drug interactions include hepatic neoplasm among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Vyvanse and Folate. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,868 Vyvanse users. Check the latest studies of Vyvanse.

What is Folate?

Folate has active ingredients of folic acid. It is often used in rheumatoid arthritis. eHealthMe is studying from 6,546 Folate users. Check the latest studies of Folate.

On Jul, 10, 2026

66 people who take Vyvanse and Folate together, and have interactions are studied.

What are the common drug interactions of Vyvanse and Folate, by gender? *:

female:

Hepatic neoplasm (liver tumour)
Hypertransaminasaemia
Hypoaesthesia (reduced sense of touch or sensation)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypotension (abnormally low blood pressure)
Immune system disorder
Impaired gastric emptying
Impaired self-care
Increased appetite
Insomnia (sleeplessness)

male:

Pyrexia (fever)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Renal injury (kidney injury)
Agitation (state of anxiety or nervous excitement)
Decreased activity
Decreased appetite
Dizziness
Drug dependence
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Vyvanse and Folate, by age (0-1 to 60+)? *:

0-1:

Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Pyrexia (fever)
Viral upper respiratory tract infection

2-9:

n/a

10-19:

Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Eye pain
Fatigue (feeling of tiredness)
Impaired gastric emptying
Kidney infection
Narcolepsy (brain's inability to regulate sleep-wake cycles normally)
Oculogyric crisis (a spasmodic movement of the eyeballs into a fixed position due to medicine reaction)

20-29:

Dizziness
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Adverse event
Bradycardia (abnormally slow heart action)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Emotional distress
Eye movement disorder
Fatigue (feeling of tiredness)
Hypertension (high blood pressure)

30-39:

Aggression
Dizziness
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Self-injurious ideation
Suicidal ideation
Anxiety
Blood pressure increased
Crying
Decreased appetite

40-49:

Chronic kidney disease
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Apathy
Aphasia (damage to the parts of the brain that control language)
Asthenia (weakness)
Blood pressure increased
Cardiac aneurysm (a condition that can occur after a myocardial infarction due to the inadequate resistance of the new scar tissue to the systolic pressure)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Angioedema (rapid swelling of the dermis)
Anxiety
Blood cholesterol increased
Breast cancer recurrent
Death
Headache (pain in head)
Heart rate increased

60+:

Fall
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Joint swelling
Muscular weakness (muscle weakness)
Myopathy (a muscular disease in which the muscle fibres do not function)
Nausea (feeling of having an urge to vomit)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Thrombocytopenia (decrease of platelets in blood)
Rib fracture

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 26 people, 39.39%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 16.67%
Depression: 9 people, 13.64%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 8 people, 12.12%
Stress And Anxiety: 5 people, 7.58%
Panic Disorder: 4 people, 6.06%
Pain: 4 people, 6.06%
Insomnia (sleeplessness): 4 people, 6.06%
Hypersensitivity: 4 people, 6.06%
High Blood Pressure: 4 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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