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Vyvanse and Nucala drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vyvanse (lisdexamfetamine dimesylate) and Nucala (mepolizumab). Common drug interactions include anxiety among females and sinusitis among males.

The phase IV clinical study analyzes what interactions people have when they take Vyvanse and Nucala. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,868 Vyvanse users. Check the latest studies of Vyvanse.

What is Nucala?

Nucala has active ingredients of mepolizumab. eHealthMe is studying from 26,883 Nucala users. Check the latest studies of Nucala.

On Jul, 18, 2026

11 people who take Vyvanse and Nucala together, and have interactions are studied.

Vyvanse and Nucala drug interactions.

What are the common drug interactions of Vyvanse and Nucala, by gender? *:

female:

  1. Anxiety
  2. Asthma
  3. Cough
  4. Drug hypersensitivity
  5. Drug ineffective
  6. Dyspnoea (difficult or laboured respiration)
  7. Eye irritation
  8. Foreign body sensation in eyes (feeling of something in eye)
  9. Hypersomnia (excessive daytime sleepiness (eds))
  10. Injection site discolouration

male:

  1. Sinusitis (inflammation of sinus)
  2. Erythema (redness of the skin)
  3. Pain
  4. Hypertension (high blood pressure)
  5. Tachycardia (a heart rate that exceeds the range of 100 beats/min)
  6. Upper respiratory tract infection
  7. Pruritus (severe itching of the skin)
  8. Rash
  9. Respiratory tract infection
  10. Skin infection

What are the common drug interactions of Vyvanse and Nucala, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Sinusitis (inflammation of sinus)

30-39:

  1. Drug ineffective
  2. Hypersomnia (excessive daytime sleepiness (eds))

40-49:

  1. Anxiety
  2. Asthma
  3. Throat tightness
  4. Cough
  5. Drug hypersensitivity
  6. Dyspnoea (difficult or laboured respiration)
  7. Eye irritation
  8. Foreign body sensation in eyes (feeling of something in eye)
  9. Injection site discolouration
  10. Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 8 people, 72.73%
  2. Asthma: 2 people, 18.18%
  3. Stress And Anxiety: 1 person, 9.09%
  4. Sinusitis (inflammation of sinus): 1 person, 9.09%
  5. Nasal Polyps (masses that develop in the lining of the nose): 1 person, 9.09%
  6. Migraine (headache): 1 person, 9.09%
  7. High Blood Pressure: 1 person, 9.09%
  8. Dyspnea (difficult or laboured breathing): 1 person, 9.09%
  9. Allergic Rhinitis: 1 person, 9.09%
  10. Agitation (state of anxiety or nervous excitement): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Vyvanse and Nucala?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Vyvanse and Nucala:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vyvanse:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Nucala:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Vyvanse and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Nucala and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on lisdexamfetamine dimesylate and mepolizumab (the active ingredients of Vyvanse and Nucala, respectively), and Vyvanse and Nucala (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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