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Vyvanse and Rapaflo drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vyvanse (lisdexamfetamine dimesylate) and Rapaflo (silodosin). Common drug interactions include diabetic neuropathy among males.

The phase IV clinical study analyzes what interactions people have when they take Vyvanse and Rapaflo. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,870 Vyvanse users. Check the latest studies of Vyvanse.

What is Rapaflo?

Rapaflo has active ingredients of silodosin. It is often used in prostate examination abnormal. eHealthMe is studying from 3,929 Rapaflo users. Check the latest studies of Rapaflo.

On Aug, 11, 2026

14 people who take Vyvanse and Rapaflo together, and have interactions are studied.

Vyvanse and Rapaflo drug interactions.

What are the common drug interactions of Vyvanse and Rapaflo, by gender? *:

female:

n/a

male:

  1. Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
  2. Haemorrhoids (a swollen vein or group of veins in the region of the anus)
  3. Facial pain
  4. Fall
  5. Lower limb fracture
  6. Visual impairment
  7. White blood cell count decreased
  8. Headache (pain in head)
  9. Neuropathy peripheral (surface nerve damage)
  10. Somnolence (a state of near-sleep, a strong desire for sleep)

What are the common drug interactions of Vyvanse and Rapaflo, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Fall
  2. Lower limb fracture

50-59:

  1. Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)

60+:

n/a

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 57.14%
  2. Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 2 people, 14.29%
  3. Polyarthritis (arthritis which involves 5 or more joints simultaneously): 1 person, 7.14%
  4. Lymphoma (cancer that begins in immune system cells): 1 person, 7.14%
  5. Lower Urinary Tract Symptoms: 1 person, 7.14%
  6. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 7.14%
  7. Birth Control: 1 person, 7.14%
  8. Arthropathy: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Vyvanse and Rapaflo:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vyvanse:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Rapaflo:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Vyvanse and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Rapaflo and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on lisdexamfetamine dimesylate and silodosin (the active ingredients of Vyvanse and Rapaflo, respectively), and Vyvanse and Rapaflo (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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