Vyvanse and Sennosides drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vyvanse (lisdexamfetamine dimesylate) and Sennosides (senna). Common drug interactions include somnolence among females and febrile neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Vyvanse and Sennosides. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,870 Vyvanse users. Check the latest studies of Vyvanse.

What is Sennosides?

Sennosides has active ingredients of senna. It is often used in constipation. eHealthMe is studying from 8,247 Sennosides users. Check the latest studies of Sennosides.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

23 people who take Vyvanse and Sennosides together, and have interactions are studied.

Vyvanse and Sennosides drug interactions.

What are the common drug interactions of Vyvanse and Sennosides, by gender? *:

female:

Somnolence (a state of near-sleep, a strong desire for sleep)
Pathological fracture (broken bone caused by disease)
Vision blurred
Visual impairment
Weight increased
Nausea (feeling of having an urge to vomit)
Reading disorder (problem in areas of the brain that help interpret language)
Acne (skin problems that cause pimples)
Adverse drug reaction
Aggression

male:

Febrile neutropenia (fever with reduced white blood cells)

What are the common drug interactions of Vyvanse and Sennosides, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Disturbance in attention
Drug intolerance (drug sensitivity)
Fluid retention (an abnormal accumulation of fluid in the blood)
Somnolence (a state of near-sleep, a strong desire for sleep)
Acne (skin problems that cause pimples)
Adverse drug reaction
Aggression
Depressive symptom
Drug ineffective
Fatigue (feeling of tiredness)

30-39:

Arthralgia (joint pain)
Cellulitis (infection under the skin)
Dizziness
Drug level decreased
Febrile neutropenia (fever with reduced white blood cells)
Gingivitis (inflammation of gums)
Hot flush (sudden feelings of heat)
Infusion related reaction
Nausea (feeling of having an urge to vomit)
Nephrolithiasis (calculi in the kidneys)

40-49:

Nausea (feeling of having an urge to vomit)
Oral pain
Febrile neutropenia (fever with reduced white blood cells)
Neutropenia (an abnormally low number of neutrophils)
Platelet count decreased

50-59:

n/a

60+:

Ankle fracture
Diplopia (double vision)
Blood iron decreased
Ear infection
Haematocrit decreased
Haemoglobin decreased
Protein total decreased
Red blood cell count decreased
Fall
Electrocardiogram qt prolonged

What are the existing conditions these people have? *

High Blood Pressure: 6 people, 26.09%
Bipolar Disorder (mood disorder): 6 people, 26.09%
Osteopenia (a condition where bone mineral density is lower than normal): 6 people, 26.09%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 6 people, 26.09%
Itching: 6 people, 26.09%
Irritable Bowel Syndrome: 6 people, 26.09%
Restless Leg Syndrome (a powerful urge to move your legs): 6 people, 26.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 26.09%
Binge Eating (pattern of disordered eating which consists of episodes of uncontrollable eating): 6 people, 26.09%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 21.74%

* Approximation only. Some reports may have incomplete information.

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