Vyvanse and Testosterone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vyvanse (lisdexamfetamine dimesylate) and Testosterone (testosterone). Common drug interactions include hallucination among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Vyvanse and Testosterone. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,872 Vyvanse users. Check the latest studies of Vyvanse.

What is Testosterone?

Testosterone has active ingredients of testosterone. It is often used in testosterone. eHealthMe is studying from 6,457 Testosterone users. Check the latest studies of Testosterone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

38 people who take Vyvanse and Testosterone together, and have interactions are studied.

Vyvanse and Testosterone drug interactions.

What are the common drug interactions of Vyvanse and Testosterone, by gender? *:

female:

Hallucination (an experience involving the perception of something not present)
Headache (pain in head)
Heart rate increased
Idiopathic urticaria (allergic reactions, presence of hives with unknown cause)
Influenza
Infusion related reaction
Kidney infection
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Nephrolithiasis (calculi in the kidneys)

male:

Fatigue (feeling of tiredness)
Pain
Dysgeusia (disorder of the sense of taste)
Headache (pain in head)
Oropharyngeal pain
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Sinus congestion (blockage of sinus)
Bone density decreased
Dysstasia (difficulty in standing)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

What are the common drug interactions of Vyvanse and Testosterone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cough
Dysgeusia (disorder of the sense of taste)
Fatigue (feeling of tiredness)
Headache (pain in head)
Insomnia (sleeplessness)
Oropharyngeal pain
Pain
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Sinus congestion (blockage of sinus)
Drug ineffective

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood testosterone decreased
Bone density decreased
Emotional distress
Feeling hot
Fracture
Gastrointestinal motility disorder (abnormal intestinal contractions)
Pain
Serum serotonin decreased

40-49:

Arthralgia (joint pain)
Arthropathy
Blood glucose decreased
Chest discomfort
Decreased appetite
Drug ineffective
Hallucination (an experience involving the perception of something not present)
Heart rate increased
Influenza
Pain

50-59:

Dry mouth
Ear pain
Escherichia sepsis (bacterial infection by escherichia coli)
Groin pain
Headache (pain in head)
Idiopathic urticaria (allergic reactions, presence of hives with unknown cause)
Infusion related reaction
Kidney infection
May-thurner syndrome (a rarely diagnosed condition in which patients develop iliofemoral deep venous thrombosis (dvt) due to an anatomical variant)
Myalgia (muscle pain)

60+:

Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Optic neuritis (optic nerve inflammation)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 36.84%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 31.58%
Drowsiness: 11 people, 28.95%
Depression: 5 people, 13.16%
Pain: 4 people, 10.53%
Hiv Infection: 3 people, 7.89%
Thyroid Diseases: 3 people, 7.89%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 7.89%
Insomnia (sleeplessness): 3 people, 7.89%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 3 people, 7.89%

* Approximation only. Some reports may have incomplete information.

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