Warfarin sodium and Pamelor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Warfarin sodium (warfarin sodium) and Pamelor (nortriptyline hydrochloride). Common drug interactions include hypercalcaemia among females and arteriovenous fistula site haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Warfarin sodium and Pamelor. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Warfarin sodium?

Warfarin sodium has active ingredients of warfarin sodium. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 71,174 Warfarin sodium users. Check the latest studies of Warfarin sodium.

What is Pamelor?

Pamelor has active ingredients of nortriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 4,069 Pamelor users. Check the latest studies of Pamelor.



On Jul, 16, 2026

22 people who take Warfarin sodium and Pamelor together, and have interactions are studied.

Warfarin sodium and Pamelor drug interactions.

What are the common drug interactions of Warfarin Sodium and Pamelor, by gender? *:

female:

  1. Hypercalcaemia (elevated calcium (ca+) level in the blood)
  2. Hyperplasia (enlargement of an organ or tissue)
  3. Hypertension (high blood pressure)
  4. Hyperventilation
  5. Hypochondriasis (health phobia or health anxiety)
  6. Impaired gastric emptying
  7. Impaired work ability
  8. Insomnia (sleeplessness)
  9. Intervertebral disc degeneration (spinal disc degeneration)
  10. Intervertebral disc protrusion (spinal disc protrusion)

male:

  1. Arteriovenous fistula site haemorrhage
  2. Cardiac arrest
  3. Osteonecrosis (death of bone)
  4. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  5. Pulse absent
  6. Renal transplant
  7. Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
  8. Sinusitis (inflammation of sinus)
  9. Bone pain
  10. Dysgeusia (disorder of the sense of taste)

What are the common drug interactions of Warfarin Sodium and Pamelor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Hepatic failure (liver failure)
  2. Hepatitis acute
  3. Liver transplant
  4. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  5. Renal transplant
  6. Sinusitis (inflammation of sinus)
  7. Abdominal pain
  8. Diarrhoea
  9. Diarrhoea haemorrhagic (bloody diarrhoea)
  10. Suicidal ideation

30-39:

n/a

40-49:

n/a

50-59:

  1. Cardiotoxicity (damage to the heart muscle)
  2. Feeling cold
  3. Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)

60+:

  1. Arteriovenous fistula site haemorrhage
  2. Cardiac arrest
  3. Oedema peripheral (superficial swelling)
  4. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  5. Osteonecrosis (death of bone)
  6. Petechiae (a small red or purple spot caused by bleeding into the skin)
  7. Pulse absent
  8. Red blood cell count decreased
  9. Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
  10. Abdominal mass (localized enlargement or swelling in the human abdomen)

What are the existing conditions these people have? *

  1. Multiple Myeloma (cancer of the plasma cells): 5 people, 22.73%
  2. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 9.09%
  3. Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 2 people, 9.09%
  4. Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Warfarin sodium and Pamelor?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Warfarin sodium and Pamelor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Warfarin sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Pamelor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Warfarin sodium and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Pamelor and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on warfarin sodium and nortriptyline hydrochloride (the active ingredients of Warfarin sodium and Pamelor, respectively), and Warfarin sodium and Pamelor (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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