Welchol and Actonel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Welchol (colesevelam hydrochloride) and Actonel (risedronate sodium). Common drug interactions include upper respiratory tract infection among females and altered state of consciousness among males.

The phase IV clinical study analyzes what interactions people have when they take Welchol and Actonel. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Welchol?

Welchol has active ingredients of colesevelam hydrochloride. It is often used in high blood cholesterol. eHealthMe is studying from 11,309 Welchol users. Check the latest studies of Welchol.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

On Jul, 27, 2026

63 people who take Welchol and Actonel together, and have interactions are studied.

What are the common drug interactions of Welchol and Actonel, by gender? *:

female:

Upper respiratory tract infection
Vaginal infection
Abdominal distension
Abdominal pain
Abdominal pain upper
Acute sinusitis
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Aphasia (damage to the parts of the brain that control language)
Arteriosclerosis (thickening and hardening of arteries)
Arthritis (form of joint disorder that involves inflammation of one or more joints)

male:

Altered state of consciousness (altered state of mind)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Chronic lymphocytic leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell))
Device failure
Dysarthria (speech disorder)
Fatigue (feeling of tiredness)
Feeling hot
Gastric varices haemorrhage (dilated submucosal veins in the stomach with bleeding)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hyperhidrosis (abnormally increased sweating)

What are the common drug interactions of Welchol and Actonel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Dizziness
Gait disturbance
Haemorrhage (bleeding)
Headache (pain in head)
Muscle spasms (muscle contraction)
Oedema peripheral (superficial swelling)
Pyrexia (fever)
Swollen tongue (swelling of tongue)
Weight decreased
Abdominal distension

60+:

Myalgia (muscle pain)
Bone disorder
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Low turnover osteopathy (slow removal of old bone and its replacement by new bone)
Pain
Pathological fracture (broken bone caused by disease)
Drug ineffective
Fatigue (feeling of tiredness)
Hypertrophy breast (increase in the volume of breast due to the enlargement of its component cells)
Oesophageal pain

What are the existing conditions these people have? *

Pain: 6 people, 9.52%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 9.52%
Hypersensitivity: 4 people, 6.35%
High Blood Pressure: 4 people, 6.35%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 6.35%
Asthma: 4 people, 6.35%

* Approximation only. Some reports may have incomplete information.

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