Welchol and Dilantin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Welchol (colesevelam hydrochloride) and Dilantin (phenytoin sodium). Common drug interactions include oesophageal candidiasis among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Welchol and Dilantin. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Welchol?

Welchol has active ingredients of colesevelam hydrochloride. It is often used in high blood cholesterol. eHealthMe is studying from 11,309 Welchol users. Check the latest studies of Welchol.

What is Dilantin?

Dilantin has active ingredients of phenytoin sodium. It is often used in epilepsy. eHealthMe is studying from 20,858 Dilantin users. Check the latest studies of Dilantin.

On Jul, 05, 2026

16 people who take Welchol and Dilantin together, and have interactions are studied.

What are the common drug interactions of Welchol and Dilantin, by gender? *:

female:

Oesophageal candidiasis (fungal infection of oesophagus)
Oesophageal stenosis (narrowing of oesophagus)
Oral candidiasis (fungal infection of mouth)
Osteoporosis (bones weak and more likely to break)
Pain
Pericardial effusion (fluid around the heart)
Pleural effusion (water on the lungs)
Productive cough
Pulmonary hypertension (increase in blood pressure in the lung artery)
Pyrexia (fever)

male:

Asthenia (weakness)
Constipation
Anxiety
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood creatinine increased
Contusion (a type of hematoma of tissue in which capillaries)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Craniopharyngioma (a type of brain tumour derived from pituitary gland embryonic tissue)
Diffuse large b-cell lymphoma (cancer of b cells, a type of white blood cell)

What are the common drug interactions of Welchol and Dilantin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Petit mal epilepsy (absence seizure)

40-49:

Gamma-glutamyltransferase increased
Alanine aminotransferase increased
Aspartate aminotransferase increased
Muscle twitching
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Simple partial seizures (seizures which affect only a small region of the brain)

50-59:

Wheezing (a high-pitched whistling sound made while you breath)
Abdominal pain
Acute sinusitis
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Arthropathy
Asthma
Blood alkaline phosphatase increased
Breast mass
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

60+:

Abdominal discomfort
Dizziness
Dizziness (excl vertigo)
Drug level decreased
Emotional distress
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
General physical health deterioration (weak health status)
Injury
Joint contracture (a permanent shortening of a muscle or joint)
Mobility decreased (ability to move is reduced)

What are the existing conditions these people have? *

Wheezing (a high-pitched whistling sound made while you breath): 1 person, 6.25%
Inflammation: 1 person, 6.25%
Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults): 1 person, 6.25%
Hypersensitivity: 1 person, 6.25%
Hyperparathyroidism Secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary): 1 person, 6.25%
Headache (pain in head): 1 person, 6.25%
Fungal Infection: 1 person, 6.25%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 1 person, 6.25%
Dyspnea (difficult or laboured breathing): 1 person, 6.25%
Dizziness: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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