Welchol and Naprosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Welchol (colesevelam hydrochloride) and Naprosyn (naproxen). Common drug interactions include rectal polyp among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Welchol and Naprosyn. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Welchol?

Welchol has active ingredients of colesevelam hydrochloride. It is often used in high blood cholesterol. eHealthMe is studying from 11,309 Welchol users. Check the latest studies of Welchol.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

On Jul, 14, 2026

57 people who take Welchol and Naprosyn together, and have interactions are studied.

What are the common drug interactions of Welchol and Naprosyn, by gender? *:

female:

Rectal polyp (fleshy growth occurring on the lining of the colon)
Rosacea (a skin condition that causes facial redness)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Urticaria (rash of round, red welts on the skin that itch intensely)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Renal tubular acidosis (medical condition that involves an accumulation of acid in the body due to a failure of the kidneys)
Oedema peripheral (superficial swelling)
Asthenia (weakness)
Pancreatitis acute (sudden inflammation of pancreas)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)

male:

Fatigue (feeling of tiredness)
Balance disorder
Tendon rupture (tear of tendon)
Tendonitis (a condition that causes pain and swelling of tendons)
Asthenia (weakness)
Anxiety
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Local swelling (swelling at the site of some application of substance or injury)
Pain in extremity
Peripheral swelling

What are the common drug interactions of Welchol and Naprosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cardiovascular disorder (heart diseases)
Delusion (a false belief or opinion)
Obstructive airways disorder (a progressive disease that makes it hard to breathe)

40-49:

Fatigue (feeling of tiredness)
Hypertension (high blood pressure)
Osteonecrosis (death of bone)
Osteopenia (a condition where bone mineral density is lower than normal)
Pancreatitis acute (sudden inflammation of pancreas)
Renal failure (kidney dysfunction)
Type 2 diabetes mellitus
Actinic keratosis (skin disease due to sun exposure)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Anaemia macrocytic (a macrocytic class of anaemia)

50-59:

Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bullous lung disease
Decreased appetite
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Herpes zoster
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypokalaemia (low potassium)
Hypotension (abnormally low blood pressure)

60+:

Fatigue (feeling of tiredness)
Balance disorder
Tendonitis (a condition that causes pain and swelling of tendons)
Peripheral coldness
Asthenia (weakness)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Local swelling (swelling at the site of some application of substance or injury)
Oedema peripheral (superficial swelling)
Pain in extremity
Peripheral swelling

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 21 people, 36.84%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 17 people, 29.82%
Hyperlipidaemia (presence of excess lipids in the blood): 17 people, 29.82%
Insomnia (sleeplessness): 15 people, 26.32%
Bone Density Decreased: 6 people, 10.53%
Stress And Anxiety: 6 people, 10.53%
Hiv Infection: 5 people, 8.77%
Bone Loss: 5 people, 8.77%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 5 people, 8.77%
Neuropathy Peripheral (surface nerve damage): 4 people, 7.02%

* Approximation only. Some reports may have incomplete information.

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