Wygesic and Prilosec drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Wygesic (acetaminophen; propoxyphene hydrochloride) and Prilosec (omeprazole). Common drug interactions include nausea among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Wygesic and Prilosec. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Wygesic?

Wygesic has active ingredients of acetaminophen; propoxyphene hydrochloride. eHealthMe is studying from 112 Wygesic users. Check the latest studies of Wygesic.

What is Prilosec?

Prilosec has active ingredients of omeprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 175,286 Prilosec users. Check the latest studies of Prilosec.

On Aug, 07, 2026

13 people who take Wygesic and Prilosec together, and have interactions are studied.

What are the common drug interactions of Wygesic and Prilosec, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Tardive dyskinesia (a disorder that involves involuntary movements)
Anxiety
Asthenia (weakness)
Blood potassium decreased
Diabetes mellitus inadequate control
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)
Dyskinesia (abnormality or impairment of voluntary movement)
Emotional disorder

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Suicide attempt
Therapeutic response decreased (less preventive response)
Vomiting
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Anxiety

What are the common drug interactions of Wygesic and Prilosec, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Blood potassium decreased
Dyskinesia (abnormality or impairment of voluntary movement)
Emotional disorder
Excessive eye blinking (excessive blinking is dry eyes)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Family stress
Gastritis (inflammation of stomach)
Impaired work ability
Pain

30-39:

n/a

40-49:

Diabetes mellitus inadequate control
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)
Nephropathy (damage to or disease of a kidney)
Neuropathy peripheral (surface nerve damage)
Type 1 diabetes mellitus

50-59:

Arthralgia (joint pain)
Asthenia (weakness)
Drug effect decreased
Glomerulonephritis (a group of conditions that affect parts of the kidneys called glomeruli)
Migraine (headache)
Photophobia (extreme sensitivity to light)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Suicide attempt
Therapeutic response decreased (less preventive response)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Death

What are the existing conditions these people have? *

High Blood Pressure: 5 people, 38.46%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 5 people, 38.46%
Type 2 Diabetes: 4 people, 30.77%
Depression: 4 people, 30.77%
Dizziness: 4 people, 30.77%
Enlarged Prostate: 4 people, 30.77%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 4 people, 30.77%
Facial Spasm (involuntary muscle contractions face): 4 people, 30.77%
Insomnia (sleeplessness): 4 people, 30.77%
Chest Pain: 4 people, 30.77%

* Approximation only. Some reports may have incomplete information.

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