Xenical and Serevent drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xenical (orlistat) and Serevent (salmeterol xinafoate). Common drug interactions include pneumoperitoneum among females and dry mouth among males.

The phase IV clinical study analyzes what interactions people have when they take Xenical and Serevent. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Xenical?

Xenical has active ingredients of orlistat. It is often used in weight loss. eHealthMe is studying from 11,722 Xenical users. Check the latest studies of Xenical.

What is Serevent?

Serevent has active ingredients of salmeterol xinafoate. It is often used in asthma. eHealthMe is studying from 15,586 Serevent users. Check the latest studies of Serevent.

On Jul, 14, 2026

49 people who take Xenical and Serevent together, and have interactions are studied.

What are the common drug interactions of Xenical and Serevent, by gender? *:

female:

Pneumoperitoneum (air or gas in the abdominal (peritoneal) cavity)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Pyelonephritis (inflammation of kidney caused by bacteria)
Respiratory failure (inadequate gas exchange by the respiratory system)
Septic shock (shock due to blood infection)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Type 2 diabetes mellitus
Weight increased
Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)

male:

Dry mouth
Hepatocellular damage (liver damage)
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
High density lipoprotein decreased
Hypocholesterolaemia (presence of abnormally small amounts of cholesterol in the circulating blood)
Impaired gastric emptying
Ingrowing nail
Lacrimation increased
Myoclonic jerks (involuntary twitching of a muscle or group of muscles)

What are the common drug interactions of Xenical and Serevent, by age (0-1 to 60+)? *:

0-1:

Aortic valve incompetence
Bicuspid aortic valve
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Neonatal respiratory distress syndrome (a serious medical condition where a newborn baby's lungs cannot provide their body with enough oxygen)
Premature baby
Tricuspid valve incompetence (inefficient heart valve)

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Acidosis (build-up of carbon dioxide in the blood)
Cardiac arrest
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Death
Fluid overload (too much fluid in the blood)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)

40-49:

Blood sodium increased
Headache (pain in head)
Myoclonic jerks (involuntary twitching of a muscle or group of muscles)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Faecal incontinence (a lack of control over passing stool)
Faeces discoloured
Faeces pale
Hypertension (high blood pressure)
Influenza
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)

50-59:

Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Ejection fraction (the percentage of blood that is pumped out of a filled ventricle as a result of a heartbeat)
Erythema (redness of the skin)
Eye irritation
Faeces hard
Frequent bowel movements
Haematocrit decreased
Heart rate decreased
Hypertension (high blood pressure)

60+:

Dyspnoea (difficult or laboured respiration)
Abdominal distension
Confusion
Diarrhoea
Dry mouth
Faeces pale
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypokalaemia (low potassium)
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Depression: 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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