Xgeva and Ifosfamide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xgeva (denosumab) and Ifosfamide (ifosfamide). Common drug interactions include drug ineffective among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Xgeva and Ifosfamide. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Xgeva?

Xgeva has active ingredients of denosumab. It is often used in breast cancer. eHealthMe is studying from 37,717 Xgeva users. Check the latest studies of Xgeva.

What is Ifosfamide?

Ifosfamide has active ingredients of ifosfamide. eHealthMe is studying from 21,285 Ifosfamide users. Check the latest studies of Ifosfamide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

11 people who take Xgeva and Ifosfamide together, and have interactions are studied.

What are the common drug interactions of Xgeva and Ifosfamide, by gender? *:

female:

Drug ineffective
Asthenia (weakness)
Blood 25-hydroxycholecalciferol decreased
Blood albumin decreased
Blood alkaline phosphatase increased
Blood chloride decreased
Blood creatinine decreased
Blood parathyroid hormone increased
Blood sodium decreased
Breast disorder

male:

Asthenia (weakness)
Fatigue (feeling of tiredness)
Osteonecrosis of jaw (death of bone of jaw)
Pulmonary embolism (blockage of the main artery of the lung)
Sarcoma metastatic (rare cancers that develop in the muscle, bone, nerves, cartilage, tendons, blood vessels and the fatty and fibrous tissues spreads to other parts)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Diarrhoea
Hypertension (high blood pressure)
Oral pain
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

What are the common drug interactions of Xgeva and Ifosfamide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Alopecia (absence of hair from areas of the body)
Drug ineffective
Limb amputation (loss of leg)
Mucosal inflammation (infection of mucous membrane)
Myelosuppression (a decrease in the production of blood cells)
Nausea (feeling of having an urge to vomit)
Osteosarcoma recurrent (reoccurrence of a cancerous (malignant) bone tumour)
Respiratory failure (inadequate gas exchange by the respiratory system)
Vomiting

20-29:

n/a

30-39:

Asthenia (weakness)
Blood 25-hydroxycholecalciferol decreased
Blood albumin decreased
Blood alkaline phosphatase increased
Blood chloride decreased
Blood creatinine decreased
Blood parathyroid hormone increased
Blood sodium decreased
Breast disorder
Breast mass

40-49:

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Leiomyosarcoma metastatic (a very rare soft tissue sarcoma (cancer) that grows in muscle tissue spreading to other parts)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Diarrhoea
Hypertension (high blood pressure)
Oral pain

50-59:

n/a

60+:

Fatigue (feeling of tiredness)
Asthenia (weakness)
Pulmonary embolism (blockage of the main artery of the lung)
Sarcoma metastatic (rare cancers that develop in the muscle, bone, nerves, cartilage, tendons, blood vessels and the fatty and fibrous tissues spreads to other parts)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Vomiting
Depressed mood
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Diarrhoea
Drug ineffective

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 4 people, 36.36%
Sarcoma (rare cancers that develop in the muscle, bone, nerves, cartilage, tendons, blood vessels and the fatty and fibrous tissues): 2 people, 18.18%
Renal Cell Carcinoma (a kidney cancer): 2 people, 18.18%
Uterine Leiomyosarcoma (uterus cancer of smooth muscle connective tissue): 1 person, 9.09%
Thyroid Diseases: 1 person, 9.09%
Sarcoma Metastatic (rare cancers that develop in the muscle, bone, nerves, cartilage, tendons, blood vessels and the fatty and fibrous tissues spreads to other parts): 1 person, 9.09%
Osteosarcoma Metastatic (a cancerous (malignant) bone tumour can spreads to other parts): 1 person, 9.09%
Osteosarcoma (a cancerous (malignant) bone tumour): 1 person, 9.09%
Metastases To Spine (cancer spreads to spine): 1 person, 9.09%
Leiomyosarcoma Metastatic (a very rare soft tissue sarcoma (cancer) that grows in muscle tissue spreading to other parts): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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