Xifaxan and Augmentin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xifaxan (rifaximin) and Augmentin (amoxicillin; clavulanate potassium). Common drug interactions include deafness among females and memory impairment among males.

The phase IV clinical study analyzes what interactions people have when they take Xifaxan and Augmentin. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Xifaxan?

Xifaxan has active ingredients of rifaximin. It is often used in irritable bowel syndrome. eHealthMe is studying from 16,609 Xifaxan users. Check the latest studies of Xifaxan.

What is Augmentin?

Augmentin has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 42,620 Augmentin users. Check the latest studies of Augmentin.

On Jul, 13, 2026

32 people who take Xifaxan and Augmentin together, and have interactions are studied.

Xifaxan and Augmentin drug interactions.

What are the common drug interactions of Xifaxan and Augmentin, by gender? *:

female:

Deafness
Dental care
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
Drug ineffective
Dry mouth
Flushing (the warm, red condition of human skin)
Gait disturbance
Gingival ulceration (ulcer on gums)
Heart rate decreased

male:

Memory impairment
Abdominal pain
Coagulopathy (blood's ability to clot is impaired)
Confusional state
Dizziness
Epistaxis (bleed from the nose)
Fluid overload (too much fluid in the blood)
Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
Haematemesis (vomiting of blood)
Haemoglobin decreased

What are the common drug interactions of Xifaxan and Augmentin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain upper
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Urticaria (rash of round, red welts on the skin that itch intensely)
Blood glucose decreased
Blood pressure decreased
Blood pressure increased
Heart rate decreased

30-39:

n/a

40-49:

Haemoglobin decreased
Hypersplenism (enlarged spleen and a decrease in one or more types of blood cells)
Hypotension (abnormally low blood pressure)
Liver transplant
Memory impairment
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Nodule (a growth of abnormal tissue)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pericardial effusion (fluid around the heart)

50-59:

Ear infection
Malaise (a feeling of general discomfort or uneasiness)
Chronic kidney disease
Renal failure (kidney dysfunction)

60+:

Back pain
Pneumonia
Fatigue (feeling of tiredness)
Flatulence (flatus expelled through the anus)
Gait disturbance
Hospitalisation
Malaise (a feeling of general discomfort or uneasiness)
Pruritus (severe itching of the skin)
Rash
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 4 people, 12.50%
Immunodeficiency Common Variable: 4 people, 12.50%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 3 people, 9.38%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 9.38%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 9.38%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 6.25%
Pain: 2 people, 6.25%
Itching: 2 people, 6.25%
High Blood Pressure: 2 people, 6.25%
Hepatocellular Carcinoma (liver cancer): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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