Xifaxan and Codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xifaxan (rifaximin) and Codeine (codeine sulfate). Common drug interactions include diarrhoea among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Xifaxan and Codeine. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Xifaxan?

Xifaxan has active ingredients of rifaximin. It is often used in irritable bowel syndrome. eHealthMe is studying from 16,609 Xifaxan users. Check the latest studies of Xifaxan.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

On Jul, 10, 2026

23 people who take Xifaxan and Codeine together, and have interactions are studied.

What are the common drug interactions of Xifaxan and Codeine, by gender? *:

female:

Diarrhoea
Drug hypersensitivity
Pneumonia
Dyspepsia (indigestion)
Allergic sinusitis
Decreased appetite
Fear of eating
Flatulence (flatus expelled through the anus)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Hospitalisation

male:

Abdominal distension
Abdominal pain
Failure to thrive (inadequate weight gain and physical growth in children)
Flatulence (flatus expelled through the anus)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Gastrointestinal hypermotility (over activity of the intestinal tract)
Gastrointestinal infection (infection of stomach and intestine)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Pneumatosis (air or gas in an abnormal location in the body)
Urine output decreased

What are the common drug interactions of Xifaxan and Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Diarrhoea
Abdominal pain
Abdominal pain upper
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Contusion (a type of hematoma of tissue in which capillaries)
Depression
Dyspepsia (indigestion)
Eye swelling
Furuncle (infection of the hair follicle)
Hypertension (high blood pressure)

30-39:

n/a

40-49:

Abdominal pain upper
Chronic kidney disease
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypogeusia (reduced ability to taste things (to taste sweet, sour, bitter, or salty substances))
Irritability
Nausea (feeling of having an urge to vomit)
Renal failure (kidney dysfunction)

50-59:

Adverse drug reaction
Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Renal failure (kidney dysfunction)

60+:

Allergic sinusitis
Decreased appetite
Seasonal allergy (allergic condition due to certain season)
Dyspepsia (indigestion)
Anorectal discomfort
Inflammatory bowel disease
Pouchitis (inflammatory bowel disease)
Frequent bowel movements
Oxygen saturation decreased
Abdominal distension

What are the existing conditions these people have? *

Depression: 6 people, 26.09%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 21.74%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 3 people, 13.04%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 13.04%
Stress And Anxiety: 2 people, 8.70%
Multiple Myeloma (cancer of the plasma cells): 2 people, 8.70%
High Blood Pressure: 2 people, 8.70%
Hepatic Encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure): 2 people, 8.70%
Asthma: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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