Xifaxan and Fentanyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xifaxan (rifaximin) and Fentanyl (fentanyl citrate). Common drug interactions include toothache among females and confusional state among males.

The phase IV clinical study analyzes what interactions people have when they take Xifaxan and Fentanyl. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Xifaxan?

Xifaxan has active ingredients of rifaximin. It is often used in irritable bowel syndrome. eHealthMe is studying from 16,609 Xifaxan users. Check the latest studies of Xifaxan.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

On Aug, 05, 2026

51 people who take Xifaxan and Fentanyl together, and have interactions are studied.

What are the common drug interactions of Xifaxan and Fentanyl, by gender? *:

female:

Toothache (tooth pain)
Abdominal distension
Abdominal pain
Adverse drug reaction
Anaemia (lack of blood)
Aphthous stomatitis (mouth ulcer)
Asthenia (weakness)
Benign familial haematuria (thin-basement-membrane nephropathy, is a kidney disease)
Blood thyroid stimulating hormone increased
Body height decreased

male:

Confusional state
Failure to thrive (inadequate weight gain and physical growth in children)
Chronic hepatic failure (long lasting liver failure)
Death
Depression
Disease recurrence
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Dysuria (painful or difficult urination)
Emotional disorder

What are the common drug interactions of Xifaxan and Fentanyl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Vertigo

20-29:

n/a

30-39:

n/a

40-49:

Anaemia (lack of blood)
Blood thyroid stimulating hormone increased
Dysphagia (a condition in which swallowing is difficult or painful)
Lethargy (tiredness)
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Rash
Stomatitis (inflammation of mucous membrane of mouth)
Abdominal distension
Chest pain

50-59:

Drug ineffective
Dyspnoea (difficult or laboured respiration)
Dysuria (painful or difficult urination)
Ear infection
Face oedema (swelling of face)
Fatigue (feeling of tiredness)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Generalised oedema (swelling all over the body)
Gingival pain (gum pain)
Glossodynia (a burning or painful sensation in the tongue)

60+:

Anxiety
Death
Emotional disorder
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Fear
Glossitis (infection of tongue with soreness)
Injury
Joint swelling
Local swelling (swelling at the site of some application of substance or injury)
Multi-organ failure (multisystem organ failure)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 11 people, 21.57%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 17.65%
Liver Disorder (liver diseases): 5 people, 9.80%
Hepatitis C: 5 people, 9.80%
Insomnia (sleeplessness): 4 people, 7.84%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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